Review Article
A Survey of Modulation of Gut Microbiota by Dietary Polyphenols
Table 2
Studies using the gastrointestinal simulators (i.e., SHIME).
| Reference | Simulator | Phenolic compound/food | Dose | Time | Microbial technique | Population increase | Population decrease |
| De Boever et al. (2000) [57] | SHIME | Soy germ powder | 2.5 g/day | 2 weeks | Plate count | Enterobacteriaceae Coliforms Lactobacillus spp. Staphylococcus spp. Clostridium spp. | |
| Kemperman et al. (2013) [31] | Twin-SHIME | Black tea extract | 3 × daily dosing (1000 mg polyphenols as total daily dose) | 2 weeks | Plate count qPCR PCR-DGGE pyrosequencing | Klebsiella spp. Enterococci Akkermansia spp. | Bifidobacteria Blautia coccoides Anaeroglobus spp. Victivallis spp. |
| Kemperman et al. (2013) [31] | Twin-SHIME | Red wine-grape extract | 3 × daily dosing (1000 mg polyphenols as total daily dose) | 2 weeks | Plate count qPCR PCR-DGGE pyrosequencing | Klebsiella spp. Alistipes spp. Cloacibacillus spp. Victivallis spp. Akkermansia spp. | Bifidobacteria Blautia coccoides group Anaeroglobus spp. Subdoligranulum spp. Bacteroides |
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