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BioMed Research International
Volume 2015, Article ID 851320, 7 pages
Research Article

Potentially Functional Polymorphisms in POU5F1 Gene Are Associated with the Risk of Lung Cancer in Han Chinese

Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing 211166, China

Received 10 September 2015; Revised 28 November 2015; Accepted 6 December 2015

Academic Editor: Robert A. Vierkant

Copyright © 2015 Rui Niu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

To search for potentially functional variation, common SNPs in POU5F1 were annotated by SNPinfo Web Server ( Among the 17 genotyped SNPs, 14 SNPs are located in transcription factor binding sites, 7 SNPs are exonic splicing enhancer (ESE) or exonic splicing silencer (ESS). Functional annotation of the 17 genotyped SNPs are summarized in Supplementary Table 1.

  1. Supplementary Material