Potentially Functional Polymorphisms in POU5F1 Gene Are Associated with the Risk of Lung Cancer in Han Chinese
Table 4
Stratified analysis on the associations of rs887468 and rs3130457 in POU5F1 with lung cancer risk.
Characteristics
rs887468 (G>A)
rs3130457 (A>G)
Case
Control
OR (95% CI)
Case
Control
OR (95% CI)
Age
0.093
0.079
≤60
450/136/10
689/185/9
1.11 (0.88–1.40)
0.392
463/124/9
705/170/8
1.09 (0.85–1.38)
0.498
>60
547/186/12
899/183/17
1.45 (1.18–1.79)
<0.001
567/169/9
921/165/13
1.46 (1.17–1.82)
<0.001
Gender
0.749
0.398
Male
712/222/15
1100/241/17
1.32 (1.09–1.59)
0.004
734/200/15
1126/219/13
1.35 (1.11–1.64)
0.003
Female
285/100/7
488/127/9
1.25 (0.95–1.65)
0.105
296/93/3
500/116/8
1.16 (0.87–1.56)
0.312
Smoking status
0.170
0.455
Current
493/133/8
697/166/13
1.08 (0.86–1.36)
0.511
503/124/7
715/152/9
1.14 (0.89–1.44)
0.296
Former
127/52/6
66/19/1
1.54 (0.9–2.64)
0.114
135/44/6
69/16/1
1.53 (0.87–2.68)
0.136
Never
377/137/8
825/183/12
1.44 (1.14–1.81)
0.002
392/125/5
842/167/11
1.37 (1.07–1.75)
0.011
Pack-years
0.331
0.680
0
377/137/8
825/183/12
1.44 (1.14–1.81)
0.002
392/125/5
842/167/11
1.37 (1.07–1.75)
0.011
0–25
193/53/6
393/85/7
1.21 (0.86–1.70)
0.270
200/47/5
403/76/6
1.19 (0.83–1.70)
0.336
>25
427/132/8
370/100/7
1.11 (0.86–1.45)
0.422
438/121/8
381/92/4
1.18 (0.90–1.56)
0.231
Histology type
0.198
0.285
Squamous cell carcinoma
370/103/8
1588/368/26
1.12 (0.88–1.42)
0.358
381/92/8
1626/335/21
1.14 (0.88–1.46)
0.319
Adenocarcinoma
627/219/14
1588/368/26
1.36 (1.15–1.62)
<0.001
649/201/10
1626/335/21
1.35 (1.13–1.62)
0.001
Wild-type homozygote/heterozygote/variant homozygote. Adjusted for age, gender, and pack-years of smoking where appropriate in additive model. for heterogeneity.
