Novel Approaches to Treatment of Advanced Melanoma: A Review on Targeted Therapy and Immunotherapy

Figure 3

T-cell activation is a consequence of two simultaneous processes, the expression of protein B7 and antigen presentation by antigen-presenting cells (APCs) to T-cell receptor. The inhibition of activated T-cells occurs as a result of the expression of CTLA-4 and PD-1 receptor on T-cells’ surface.