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BioMed Research International
Volume 2015, Article ID 851841, 7 pages
http://dx.doi.org/10.1155/2015/851841
Review Article

Regulation of miRNAs Affects Radiobiological Response of Lung Cancer Stem Cells

1Cancer Institute of PLA, Xinqiao Hospital, Third Military Medical University, Shapingba District, Chongqing 400037, China
2Medical English Department, College of Basic Medicine, Third Military Medical University, Shapingba District, Chongqing 400038, China

Received 17 December 2014; Accepted 14 February 2015

Academic Editor: Sherven Sharma

Copyright © 2015 Yan-mei Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Radiotherapy (RT) is a key therapeutic strategy for lung cancer, the most common cause of cancer-related deaths worldwide, but radioresistance often occurs and leads to failure of RT. It is therefore important to clarify the mechanism underlying radioresistance in lung cancer. Cancer stem cells (CSCs) are considered the fundamental reason for radioresistance. MicroRNAs (miRNAs) have been regarded as important regulatory molecules of CSCs, carcinogenesis, and treatment response of cancers. It is crucial to clarify how regulation of miRNAs affects repair of DNA damage, redistribution, repopulation, reoxygenation, and radiosensitivity (5R) of lung cancer stem cells (LCSCs). A thorough understanding of the regulation of miRNAs affecting 5R of LCSCs has potential impact on identifying novel targets and thus may improve the efficacy of lung cancer radiotherapy.