Regulation of miRNAs Affects Radiobiological Response of Lung Cancer Stem Cells

Figure 1

MiRNAs regulate 5R of lung cancer stem cells (LCSCs). After irradiation, lung tumor size is reduced while LCSCs are enriched in the remaining tumors. An aberrant miRNA profile in LCSCs includes over- and underexpressed miRNAs. Thus, DNA repair and repopulation of LCSCs are enhanced, whereas redistribution and reoxygenation are blocked, and radiosensitivity decreases, leading to radioresistance.