Regulation of miRNAs Affects Radiobiological Response of Lung Cancer Stem Cells

Table 2

Regulatory miRNAs involved in radiobiological response of LCSCs.

miRNAs	Target genes	Signaling pathway	Radiobiology	Response	References
miR-145	Oct4	Oct4/Sox2/Fascin1	Radiosensitivity	Radiosensitive	[29, 30]
miR-18a	ATM	ATM	Repair of DNA	Radiosensitive	[31]
miR-7	DNA-PK	DNA-PK	Repair of DNA	Radiosensitive	[32]
miR-101	DNA-PK; ATM	DNA-PK; ATM	Repair of DNA	Radiosensitive	[33, 34]
miR-210	ISCU1/2, etc	HIF-1	Repair of DNA; Reoxygenation	Radioresistant	[35]
miR-574-5p	Ches1	TLR9	Redistribution	Radioresistant	[36]
miR-193b	cyclin D1; uPA	G1 arrest	Redistribution	Radiosensitive	[37]
miR-26a	EZH2	G1/S transition	Redistribution	Radiosensitive	[38]
miR-23a/24/27a	HMGN2; E-cadherin	TGF-β; TNF-α	Repopulation	Radioresistant	[39, 40]
miR-663	TGFB1	TGF-β	Repopulation	Radioresistant	[41]
miR-155	FOXO3A	Senescence,; apoptosis	Reoxygenation	Radioresistant	[42]
let-7a	Kras	Kras	Radiosensitivity	Radioresistant	[43]
lin28	let-7	Kras	Radiosensitivity	Radiosensitive	[43, 44]
let-7g	NF-κB1	NF-κB1	Radiosensitivity	Radioresistant	[44, 45]
miR-214	FoxO4	Senescence	Radiosensitivity	Radioresistant	[46]
miR-34 family	BCL2	p53	Radiosensitivity	Different	[47]