Clique-Based Clustering of Correlated SNPs in a Gene Can Improve Performance of Gene-Based Multi-Bin Linear Combination Test

Table 1

Quantitative trait models used for power comparisons of MLC-LD and MLC-CL.

Model name	Description	Trait model parameters^*
Model A	One causal SNP within a gene
Model B	Two causal SNPs, both deleterious
Model C	Two causal SNPs, one deleterious and one protective
Model D	1~4 causal SNPs, random assignment of the direction of effects	is randomly selected from the where SD is the expected standard deviation of

The trait model is where , is the number of causal SNPs, is the effect of th causal SNP, and is the number of causal alleles for the th causal SNP. The variance is adjusted to make the power of Wald test 60% for each set of causal SNPs for Models A, B, and C and set to 1 for Model D.