Effect of the Common Fat Mass and Obesity Associated Gene Variants on Obesity in Pakistani Population: A Case-Control Study
Table 3
Effect of selected SNPs on various anthropometric and biochemical parameters in the study subjects.
Parameter
rs9939609
rs8050136
rs1121980
rs9926289
Weight
TT TA AA
73.91 ± 20.90 74.02 ± 20.79 81.74 ± 20.66
CC CA AA
71.39 ± 20.32 76.68 ± 21.25 75.55 ± 20.70
GG GA AA
71.95 ± 20.93 75.39 ± 20.41 84.31 ± 20.54
GG GA AA
71.85 ± 20.33 76.52 ± 21.84 80.20 ± 17.92
β per risk allele value
0.079 0.084
0.081 0.075
0.041 0.102
0.133 0.004
BMI
TT TA AA
27.38 ± 6.36 29.01 ± 6.48 30.39 ± 5.77
CC CA AA
28.71 ± 6.31 29.76 ± 6.48 30.45 ± 6.15
GG GA AA
28.74 ± 6.27 29.58 ± 6.34 31.15 ± 6.58
GG GA AA
27.83 ± 5.56 30.10 ± 6.54 33.57 ± 6.90
β per risk allele value
0.126 0.010
0.151 0.001
0.188 0.004
0.272 0.001
WC
TT TA AA
86.07 ± 12.42 87.09 ± 11.73 88.00 ± 12.79
CC CA AA
85.79 ± 11.20 87.22 ± 12.15 85.58 ± 13.50
GG GA AA
82.94 ± 11.85 84.70 ± 12.40 87.12 ± 12.68
GG GA AA
81.70 ± 12.03 86.45 ± 10.91 89.92 ± 16.22
β per risk allele value
0.019 0.011
0.009 0.101
0.102 0.011
0.131 0.001
HC
TT TA AA
88.14 ± 13.07 87.27 ± 12.17 89.39 ± 12.45
CC CA AA
88.66 ± 12.07 87.37 ± 12.58 88.29 ± 13.62
GG GA AA
87.48 ± 12.36 88.62 ± 12.52 87.05 ± 14.14
GG GA AA
88.54 ± 12.49 87.32 ± 11.79 88.39 ± 15.95
β per risk allele value
0.007 0.919
0.114 0.007
0.008 0.907
0.021 0.744
WHR
TT TA AA
1.00 ± 0.07 1.00 ± 0.08 0.98 ± 0.05
CC CA AA
0.99 ± 0.06 1.00 ± 0.07 1.01 ± 0.08
GG GA AA
1.01 ± 0.08 0.99 ± 0.06 1.01 ± 0.07
GG GA AA
1.01 ± 0.06 0.99 ± 0.07 1.01 ± 0.10
β per risk allele value
0.059 0.362
0.063 0.33
0.058 0.37
0.02 0.761
Total Cholesterol (mmol/L)
TT TA AA
4.99 ± 1.08 5.09 ± 1.26 5.49 ± 1.09
CC CA AA
4.90 ± 1.05 5.15 ± 1.19 5.18 ± 1.22
GG GA AA
5.01 ± 1.16 5.10 ± 1.18 5.19 ± 1.01
GG GA AA
5.05 ± 1.26 5.04 ± 1.03 5.31 ± 1.09
β per risk allele value
0.116 0.059
0.99 0.033
0.137 0.006
0.05 0.28
Triglycerides (mmol/L)
TT TA AA
2.30 ± 0.75 2.37 ± 0.94 2.63 ± 0.81
CC CA AA
2.36 ± 0.84 2.32 ± 0.76 2.39 ± 0.97
GG GA AA
2.31 ± 0.78 2.40 ± 0.90 2.32 ± 0.76
GG GA AA
2.30 ± 0.80 2.43 ± 0.91 2.28 ± 0.67
β per risk allele value
0.099 0.031
0.011 0.809
0.125 0.009
0.033 0.472
HDL-c (mmol/L)
TT TA AA
1.44 ± 0.45 1.43 ± 0.50 1.29 ± 0.29
CC CA AA
1.50 ± 0.48 1.39 ± 0.45 1.36 ± 0.43
GG GA AA
1.49 ± 0.47 1.40 ± 0.46 1.22 ± 0.32
GG GA AA
1.47 ± 0.49 1.39 ± 0.43 1.30 ± 0.38
β per risk allele value
−0.079 0.083
−0.013 0.111
−0.015 0.102
−0.116 0.011
LDL-c (mmol/L)
TT TA AA
2.56 ± 0.74 2.67 ± 0.74 2.76 ± 0.70
CC CA AA
2.48 ± 0.78 2.70 ± 0.71 2.67 ± 0.69
GG GA AA
2.61 ± 0.73 2.60 ± 0.77 2.75 ± 0.63
GG GA AA
2.54 ± 0.71 2.65 ± 0.77 2.84 ± 0.67
β per risk allele value
0.098 0.034
0.009 0.112
0.019 0.677
0.122 0.008
FPG (mg/dL)
101.91 ± 13.52 103.21 ± 17.65 107.92 ± 16.54
98.45 ± 11.01 99.17 ± 14.75 99.07 ± 13.04
100.01 ± 10.52 99.24 ± 17.05 101.92 ± 13.14
102.41 ± 12.02 101.27 ± 16.25 102.12 ± 11.51
β per risk allele value
0.198 0.006
0.019 0.112
0.019 0.277
0.002 0.208
Legend: Values are indicated as mean ± SD. BMI: body mass index, WC: waist circumference, HC: hip circumference, WHR: waist to hip ratio, FPG: fasting plasma glucose, HDL-c: high density lipoprotein cholesterol, LDL-c: low density lipoprotein cholesterol. Analysis was done for cases and controls combined. indicates a significant association.
