The Protective Effect of Melatonin on Neural Stem Cell against LPS-Induced Inflammation

Figure 5

SOX2 and TLX mRNA expression after melatonin treatment in LPS-induced inflammation. (a) SOX2, (b) TLX, and (c) FGFR-2 mRNA levels were measured by using RT-PCR. The LPS (100 ng/mL) treatment group showed lower mRNA levels of SOX2, TLX, and FGFR-2 compared to the normal control group. Melatonin (100 nM) treatment resulted in higher SOX2 and FGFR-2 mRNA levels compared to the LPS (100 ng/mL) treatment group. In the LPS (100 ng/mL) plus melatonin (100 nM) treatment group, SOX2, TLX, and FGFR-2 mRNA levels were higher compared to the LPS (100 ng/mL) only treatment group. Data were expressed as mean ± S.E.M, and each experiment included 3 repeats per condition. Differences were considered significant at , (compared to the control group).