Research Article
Ghrelin Improves Functional Survival of Engrafted Adipose-Derived Mesenchymal Stem Cells in Ischemic Heart through PI3K/Akt Signaling Pathway
Figure 2
Ghrelin reduced ADMSCs apoptosis and promoted ADMSCs proliferation after H/SD injury. ((a), (b)) In vitro BLI also confirmed that ghrelin at 10−8 mol/L enhanced the impaired viability of ADMSCs after H/SD injury. However, the protective effect of ghrelin was abolished by the PI3K inhibitor LY294002. (c) MTT assay for four groups. (d) MTT assay for H/SD for 6, 12, and 24 hours in different ghrelin pretreatment groups. versus control group, versus H/SD group, and versus ghrelin (10−8 M) group.
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