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BioMed Research International
Volume 2015, Article ID 859073, 8 pages
http://dx.doi.org/10.1155/2015/859073
Review Article

Intramyocardial Hemorrhage: An Enigma for Cardiac MRI?

1Department of Cardiovascular, Respiratory, Nephrologic and Geriatric Sciences, La Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
2Department of Radiology, La Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy

Received 31 January 2014; Revised 25 September 2014; Accepted 8 October 2014

Academic Editor: Jiang Du

Copyright © 2015 Camilla Calvieri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. H. Rezkalla and R. A. Kloner, “Coronary no-reflow phenomenon: from the experimental laboratory to the cardiac catheterization laboratory,” Catheterization and Cardiovascular Interventions, vol. 72, no. 7, pp. 950–957, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Niccoli, F. Burzotta, L. Galiuto, and F. Crea, “Myocardial no-reflow in humans,” Journal of the American College of Cardiology, vol. 54, no. 4, pp. 281–292, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Niccoli, N. Cosentino, C. Spaziani, F. Fracassi, G. Tarantini, and F. Crea, “No-reflow: incidence and detection in the cath-lab,” Current Pharmaceutical Design, vol. 19, no. 25, pp. 4564–4575, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. S. C. A. M. Bekkers, M. W. Smulders, V. L. Passos et al., “Clinical implications of microvascular obstruction and intramyocardial haemorrhage in acute myocardial infarction using cardiovascular magnetic resonance imaging,” European Radiology, vol. 20, no. 11, pp. 2572–2578, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. C. S. Lotan, A. Bouchard, G. B. Cranney, S. P. Bishop, and G. M. Pohost, “Assessment of post reperfusion myocardial hemorrhage using proton NMR imaging at 1.5 T,” Circulation, vol. 86, no. 3, pp. 1018–1025, 1992. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Ganame, G. Messalli, S. Dymarkowski et al., “Impact of myocardial haemorrhage on left ventricular function and remodelling in patients with reperfused acute myocardial infarction,” European Heart Journal, vol. 30, no. 12, pp. 1440–1449, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. A. M. Beek, R. Nijveldt, and A. C. Van Rossum, “Intramyocardial hemorrhage and microvascular obstruction after primary percutaneous coronary intervention,” International Journal of Cardiovascular Imaging, vol. 26, no. 1, pp. 49–55, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. S. F. Pedersen, S. A. Thrysøe, M. P. Robich et al., “Assessment of intramyocardial hemorrhage by T1-weighted cardiovascular magnetic resonance in reperfused acute myocardial infarction,” Journal of Cardiovascular Magnetic Resonance, vol. 14, no. 1, article 59, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. K. C. Wu, E. A. Zerhouni, R. M. Judd et al., “Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction,” Circulation, vol. 97, no. 8, pp. 765–772, 1998. View at Publisher · View at Google Scholar · View at Scopus
  10. S. de Waha, S. Desch, I. Eitel et al., “Relationship and prognostic value of microvascular obstruction and infarct size in ST-elevation myocardial infarction as visualized by magnetic resonance imaging,” Clinical Research in Cardiology, vol. 101, no. 6, pp. 487–495, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. S. K. White, D. J. Hausenloy, and J. C. Moon, “Imaging the myocardial microcirculation post-myocardial infarction,” Current Heart Failure Reports, vol. 9, no. 4, pp. 282–292, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. A. T. Yan, C. M. Gibson, E. Larose et al., “Characterization of microvascular dysfunction after acute myocardial infarction by cardiovascular magnetic resonance first-pass perfusion and late gadolinium enhancement imaging,” Journal of Cardiovascular Magnetic Resonance, vol. 8, no. 6, pp. 831–837, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Cochet, A. Lalande, L. Lorgis et al., “Prognostic value of microvascular damage determined by cardiac magnetic resonance in non ST-segment elevation myocardial infarction: comparison between first-pass and late gadolinium-enhanced images,” Investigative Radiology, vol. 45, no. 11, pp. 725–732, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. R. M. Judd, C. H. Lugo-Olivieri, M. Arai et al., “Physiological basis of myocardial contrast enhancement in fast magnetic resonance images of 2-day-old reperfused canine infarcts,” Circulation, vol. 92, no. 7, pp. 1902–1910, 1995. View at Publisher · View at Google Scholar · View at Scopus
  15. J. A. Lima, R. M. Judd, A. Bazille, S. P. Schulman, E. Atalar, and E. A. Zerhouni, “Regional heterogeneity of human myocardial infarcts demonstrated by contrast-enhanced MRI: potential mechanisms,” Circulation, vol. 92, no. 5, pp. 1117–1125, 1995. View at Publisher · View at Google Scholar · View at Scopus
  16. V. Hombach, O. Grebe, N. Merkle et al., “Sequelae of acute myocardial infarction regarding cardiac structure and function and their prognostic significance as assessed by magnetic resonance imaging,” European Heart Journal, vol. 26, no. 6, pp. 549–557, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Ørn, C. Manhenke, O. J. Greve et al., “Microvascular obstruction is a major determinant of infarct healing and subsequent left ventricular remodelling following primary percutaneous coronary intervention,” European Heart Journal, vol. 30, no. 16, pp. 1978–1985, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Hirsch, R. Nijveldt, J. D. E. Haeck et al., “Relation between the assessment of microvascular injury by cardiovascular magnetic resonance and coronary Doppler flow velocity measurements in patients with acute anterior wall myocardial infarction,” Journal of the American College of Cardiology, vol. 51, no. 23, pp. 2230–2238, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Appelbaum, A. J. Kirtane, A. Clark et al., “Association of TIMI myocardial perfusion grade and ST-segment resolution with cardiovascular magnetic resonance measures of microvascular obstruction and infarct size following ST-segment elevation myocardial infarction,” Journal of Thrombosis and Thrombolysis, vol. 27, no. 2, pp. 123–129, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. I. Porto, F. Burzotta, M. Brancati et al., “Relation of myocardial blush grade to microvascular perfusion and myocardial infarct size after primary or rescue percutaneous coronary intervention,” The American Journal of Cardiology, vol. 99, no. 12, pp. 1671–1673, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Nijveldt, A. M. Beek, A. Hirsch et al., “Functional recovery after acute myocardial infarction: comparison between angiography, electrocardiography, and cardiovascular magnetic resonance measures of microvascular injury,” Journal of the American College of Cardiology, vol. 52, no. 3, pp. 181–189, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Tarantini, R. Razzolini, L. Cacciavillani et al., “Influence of transmurality, infarct size, and severe microvascular obstruction on left ventricular remodeling and function after primary coronary angioplasty,” American Journal of Cardiology, vol. 98, no. 8, pp. 1033–1040, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Adamo, C. B. Ducci, M. Mancone et al., “Extra-Hospital delays correlate more strongly with myocardial damage in stemi, evaluated by cardiac magnetic resonance,” Circulation, vol. 128, supplement 22, abstract 14922, 2013. View at Google Scholar
  24. D. Garcia-Dorado, P. Théroux, J. Solares et al., “Determinants of hemorrhagic infarcts: histologic observations from experiments involving coronary occlusion, coronary reperfusion, and reocclusion,” American Journal of Pathology, vol. 137, no. 2, pp. 301–311, 1990. View at Google Scholar · View at Scopus
  25. H. Fujiwara, T. Onodera, M. Tanaka et al., “A clinicopathologic study of patients with hemorrhagic myocardial infarction treated with selective coronary thrombolysis with urokinase,” Circulation, vol. 73, no. 4, pp. 749–757, 1986. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Kidambi, A. N. Mather, M. Motwani et al., “The effect of microvascular obstruction and intramyocardial hemorrhage on contractile recovery in reperfused myocardial infarction: insights from cardiovascular magnetic resonance,” Journal of Cardiovascular Magnetic Resonance, vol. 15, no. 1, article 58, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Kali, A. Kumar, I. Cokic et al., “Chronic manifestation of postreperfusion intramyocardial hemorrhage as regional iron deposition: a cardiovascular magnetic resonance study with ex vivo validation,” Circulation: Cardiovascular Imaging, vol. 6, no. 2, pp. 218–228, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Kali, R. L. Q. Tang, A. Kumar, J. K. Min, and R. Dharmakumar, “Detection of acute reperfusion myocardial hemorrhage with cardiac MR imaging: T2 versus T2,” Radiology, vol. 269, no. 2, pp. 387–395, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. A. N. Mather, T. A. Fairbairn, S. G. Ball, J. P. Greenwood, and S. Plein, “Reperfusion haemorrhage as determined by cardiovascular MRI is a predictor of adverse left ventricular remodelling and markers of late arrhythmic risk,” Heart, vol. 97, no. 6, pp. 453–459, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. I. Eitel, K. Kubusch, O. Strohm et al., “Prognostic value and determinants of a hypointense infarct core in T2-weighted cardiac magnetic resonance in acute reperfused ST-elevation- myocardial infarction,” Circulation: Cardiovascular Imaging, vol. 4, no. 4, pp. 354–362, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. K. Ochiai, T. Shimada, Y. Murakami et al., “Hemorrhagic myocardial infarction after coronary reperfusion detected in vivo by magnetic resonance imaging in humans: prevalence and clinical implications,” Journal of Cardiovascular Magnetic Resonance, vol. 1, no. 3, pp. 247–256, 1999. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Asanuma, K. Tanabe, K. Ochiai et al., “Relationship between progressive microvascular damage and intramyocardial hemorrhage in patients with reperfused anterior myocardial infarction: myocardial contrast echocardiographic study,” Circulation, vol. 96, no. 2, pp. 448–453, 1997. View at Publisher · View at Google Scholar · View at Scopus
  33. W. G. Bradley Jr., “MR appearance of hemorrhage in the brain,” Radiology, vol. 189, no. 1, pp. 15–26, 1993. View at Publisher · View at Google Scholar · View at Scopus
  34. P. M. Parizel, S. Makkat, E. van Miert, J. W. van Goethem, L. Van den Hauwe, and A. M. De Schepper, “Intracranial hemorrhage: principles of CT and MRI interpretation,” European Radiology, vol. 11, no. 9, pp. 1770–1783, 2001. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Kumar, J. D. Green, J. M. Sykes et al., “Detection and quantification of myocardial reperfusion hemorrhage Using T2-weighted CMR,” JACC: Cardiovascular Imaging, vol. 4, no. 12, pp. 1274–1283, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. S. F. Pedersen, S. A. Thrysøe, M. P. Robich et al., “Assessment of intramyocardial hemorrhage by T1-weighted cardiovascular magnetic resonance in reperfused acute myocardial infarction,” Journal of Cardiovascular Magnetic Resonance, vol. 14, no. 1, article 59, 2012. View at Publisher · View at Google Scholar · View at Scopus
  37. D. Kandler, C. Lücke, M. Grothoff et al., “The relation between hypointense core, microvascular obstruction and intramyocardial haemorrhage in acute reperfused myocardial infarction assessed by cardiac magnetic resonance imaging,” European Radiology, 2014. View at Publisher · View at Google Scholar
  38. J. Machac, S. L. Bacharach, T. M. Bateman et al., “Positron emission tomography myocardial perfusion and glucose metabolism imaging,” Journal of Nuclear Cardiology, vol. 13, no. 6, pp. e121–e151, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. J. Knuuti, H. R. Schelbert, and J. J. Bax, “The need for standardisation of cardiac FDG PET imaging in the evaluation of myocardial viability in patients with chronic ischaemic left ventricular dysfunction,” European Journal of Nuclear Medicine, vol. 29, no. 9, pp. 1257–1266, 2002. View at Publisher · View at Google Scholar · View at Scopus
  40. Y.-X. Ye, T. C. Basse-Lüsebrink, P.-A. Arias-Loza et al., “Monitoring of monocyte recruitment in reperfused myocardial infarction with intramyocardial hemorrhage and microvascular obstruction by combined fluorine 19 and proton cardiac magnetic resonance imaging,” Circulation, vol. 128, no. 17, pp. 1878–1888, 2013. View at Publisher · View at Google Scholar · View at Scopus
  41. W. W. Lee, B. Marinelli, A. M. van der Laan et al., “PET/MRI of inflammation in myocardial infarction,” Journal of the American College of Cardiology, vol. 59, no. 2, pp. 153–163, 2012. View at Publisher · View at Google Scholar · View at Scopus
  42. C. Nappi and G. El Fakhri, “State of the art in cardiac hybrid technology: PET/MR,” Current Cardiovascular Imaging Reports, vol. 6, no. 4, pp. 338–345, 2013. View at Publisher · View at Google Scholar · View at Scopus
  43. U. Flogel, Z. Ding, H. Hardung et al., “In vivo monitoring of inflammation after cardiac and cerebral ischemia by fluorine magnetic resonance imaging,” Circulation, vol. 118, no. 2, pp. 140–148, 2008. View at Publisher · View at Google Scholar · View at Scopus