Role of NEK2A in Human Cancer and Its Therapeutic Potentials

Table 1

NEK2A interaction proteins and their functions.

NEK2A interaction protein	Detection method	Function	Reference number
APC/C	Co-IP	NEK2A degradation	[23]
PP1	Yeast two-hybrid, Co-IP	NEK2A dephosphorylation	[26, 27]
C-Nap1	Yeast two-hybrid	Centrosome separation	[28]
Rootletin	Yeast two-hybrid	Centrosome separation	[29]
NLP2	Yeast two-hybrid	Microtubule organization	[33]
Numatrin	Co-IP, pull-down	Centrosome integrity and dynamics	[37]
HMGA2	Co-IP, pull-down	Chromatin condensation	[38]
HEC1	Co-IP	Spindle assembly checkpoint, chromosome separation	[42]
MAD1	Yeast two-hybrid, Co-IP	Spindle assembly checkpoint, chromosome separation	[40]
TRF1	Yeast two-hybrid, pull-down	Chromosome separation	[41]
MAD2	Co-IP	Spindle assembly checkpoint, chromosome separation	[12]
SGO1	Pull-down, Co-IP	Chromosome congression	[43]