Role of NEK2A in Human Cancer and Its Therapeutic Potentials

Table 2

Aberrant expression of NEK2A in different cancers.

Cancer type	NEK2A upregulation	Detect method	Reference number
Ewing tumor	Cancer cell line	DNA microarray analysis	[45]
Cholangiocarcinoma	Cancer cell line	RT-PCR, Western blot	[46]
Testicular seminomas	Cancer cell line and tumor tissue	Immunohistochemistry, Western blot	[47]
Breast cancer	Cancer cell line and tumor tissue	RT-PCR, Western blot, immunohistochemistry, and DNA microarray analysis	[48–52]
Cervical cancer	Cancer cell line	Western blot	[50]
Prostate cancer	Cancer cell line	Western blot	[50]
Colorectal cancer	Cancer cell line and tumor tissue	Western blot, DNA microarray analysis, and immunohistochemistry	[53, 54]
Malignant peripheral nerve sheath tumors	Tumor tissue	DNA microarray analysis, immunohistochemistry	[55]
Lung adenocarcinoma	Tumor tissue	DNA microarray analysis, immunohistochemistry, immunofluorescence	[12, 56]
Renal cell carcinoma	Tumor tissue	DNA microarray analysis	[57]
Pancreatic ductal adenocarcinoma	Tumor tissue	Real-time PCR, immunohistochemistry	[58]
Multiple myeloma	Cancer cell line and tumor tissue	DNA microarray analysis	[12]
Myeloid leukemia	Tumor tissue	DNA microarray analysis	[12]
Mantle cell lymphoma	Tumor tissue	DNA microarray analysis	[12]
Mesothelioma	Tumor tissue	DNA microarray analysis	[12]
Head and neck squamous cell carcinoma	Tumor tissue	DNA microarray analysis	[12]
Bladder carcinoma	Tumor tissue	DNA microarray analysis	[12]
Glioblastoma	Tumor tissue	DNA microarray analysis	[12]
T cell acute lymphoblastic leukemia	Tumor tissue	DNA microarray analysis	[12]
Hepatocellular carcinoma	Tumor tissue	DNA microarray analysis	[12]
Melanoma	Tumor tissue	DNA microarray analysis	[12]
Ovarian adenocarcinoma	Tumor tissue	DNA microarray analysis	[12]