Role of NEK2A in Human Cancer and Its Therapeutic Potentials

Table 3

Signaling involved in the tumorigenic function of NEK2A.

Proteins or signaling pathways interact with NEK2A	The relationship with NEK2A	Function	Reference number
Upstream of NEK2A
MAPK pathway	Phosphorylate NEK2A	Tumorigenesis	[39]
MST2	Regulate NEK2A’s ability to localize to centrosome and phosphorylate C-Nap1 and Rootletin	Tumorigenesis	[59]
PLK1	Regulate MST2-NEK2A/NEK2A--catenin-induced centrosome separation and NEK2A-NIP-induced microtubule organization	Tumorigenesis	[32, 60, 61]
CDK4	Regulate NEK2A expression	Tumorigenesis	[62]
Downstream of NEK2A
CDC20	Phosphorylated by NEK2A	Tumorigenesis	[63]
MAD2	Phosphorylated by NEK2A	Tumorigenesis	[63]
HEC1	Phosphorylated by NEK2A	Tumorigenesis	[42]
TRF1	Phosphorylated by NEK2A	Tumorigenesis	[64]
AKT	Phosphorylated by NEK2A	Tumor progression and drug resistance	[12]
-Catenin	NEK2A induces nuclear accumulation of -catenin	Tumor progression and drug resistance	[12]
ABCB1	Upregulated by NEK2A	Drug resistance	[12]
ABCC1	Upregulated by NEK2A	Drug resistance	[12]
ABCG2	Upregulated by NEK2A	Drug resistance	[12]
BAD	Downregulated by NEK2A	Drug resistance	[12]
PUMA	Downregulated by NEK2A	Drug resistance	[12]
BCL-XL	Upregulated by NEK2A	Drug resistance	[12]
MCL-1	Upregulated by NEK2A	Drug resistance	[12]
PARP	Activated in NEK2A silenced cancer cell	Drug resistance	[12]
Caspase-3	Activated in NEK2A silenced cancer cell	Drug resistance	[12]
Caspase-8	Activated in NEK2A silenced cancer cell	Drug resistance	[12]
Caspase-9	Activated in NEK2A silenced cancer cell	Drug resistance	[12]
RB	Activated in NEK2A silenced cancer cell	Drug resistance	[65]
Histone H3 (p-Ser10)	Inactivated in NEK2A silenced cancer cell	Drug resistance	[65]