Shear Stress Induces Differentiation of Endothelial Lineage Cells to Protect Neonatal Brain from Hypoxic-Ischemic Injury through NRP1 and VEGFR2 Signaling
The ASCs and ELCs were transplanted into the neonatal rats to investigate the protection of cell-based therapy in hypoxic-ischemic (HI) brain injury. Significant preservation of brain damage was observed in ELCs treatment as compared to the PBS injection (a). Both ASCs and ELCs therapies showed prevention of brain loss in Nissl staining after HI injury (b). , < 0.05 compared to PBS-treated rats.