Arsenic and Mercury Containing Traditional Chinese Medicine (Realgar and Cinnabar) Strongly Inhibit Organic Anion Transporters, Oat1 and Oat3, In Vivo in Mice

Figure 4

Expression levels of (a) Oat1 and (b) Oat3 mRNA in the kidney tissue of mice after treatment with investigational samples. C-1: water control group; C-2: 0.5% CMC-Na group; C-3: probenecid group. Higher dosages were expressed by I, and lower dosages were expressed by II. A: Realgar, B: levigated Realgar, D: Cinnabar, and E: HgCl₂. All data were expressed as percentages referred to the corresponding control, and are expressed mean ± s.d. (). Asterisks sign designates significant differences. versus C-1/C-2; versus C-1/C-2.

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