Arsenic and Mercury Containing Traditional Chinese Medicine (Realgar and Cinnabar) Strongly Inhibit Organic Anion Transporters, Oat1 and Oat3, In Vivo in Mice

Table 2

Major pharmacokinetic parameters in mice sera after a single dose of PAH.

Groups	/min	VdT/L·kg^−1	CLT/mL·min^−1·kg^−1	/g·L^−1·min
C-1	9.88 ± 0.83	0.423 ± 0.05	53.2 ± 5.3	0.464 ± 0.043
C-2	10.06 ± 0.71	0.428 ± 0.03	51.9 ± 3.4	0.474 ± 0.030
C-3	11.57 ± 1.59	0.302 ± 0.01	33.9 ± 2.7	0.721 ± 0.053
A-I	10.05 ± 1.45	0.331 ± 0.03	41.5 ± 3.7	0.599 ± 0.045
A-II	10.91 ± 0.86	0.325 ± 0.02	43.7 ± 2.6	0.555 ± 0.037
B-I	11.07 ± 1.50	0.346 ± 0.03	40.5 ± 4.1	0.608 ± 0.049
B-II	10.13 ± 0.90	0.387 ± 0.04	46.2 ± 5.2	0.539 ± 0.054
D-I	10.83 ± 1.33	0.352 ± 0.03	41.9 ± 3.9	0.585 ± 0.045
D-II	10.68 ± 0.91	0.378 ± 0.03	46.7 ± 5.0	0.527 ± 0.054
E-I	12.40 ± 2.08	0.320 ± 0.02	36.6 ± 3.2	0.660 ± 0.040
E-II	11.89 ± 1.17	0.329 ± 0.03	41.8 ± 3.7	0.579 ± 0.048

Note: C-1: water control group; C-2: 0.5% CMC-Na group; C-3: probenecid group. Higher dosages were expressed by I, and lower dosages were expressed by II. A: Realgar, B: levigated Realgar, D: Cinnabar, and E: HgCl₂ (full text). elimination half-life, CL_T total clearance, Vd_T total volume of distribution, and AUC area under curve. The results are expressed as the mean ± s.d.; ; in comparison with C-1 (LSD test).