Tanshinone IIA Attenuates Renal Fibrosis after Acute Kidney Injury in a Mouse Model through Inhibition of Fibrocytes Recruitment

Figure 2

Tanshinone IIA reduces collagen deposition in the kidney 28 days after folic acid injury. (a) Representative Masson-stained sections of renal cortices at day 28 (original magnification ×200). (b) Semiquantification of kidney fibrosis score from Masson-stained sections. (c) Total kidney collagen content determined by hydroxyproline detection among different groups (). Data are expressed as the mean ± SEM ( or 9). ^★ versus group TS; ^★★ versus group FA. Notes: Ctrl: mice treated with vehicle alone; TS: mice treated with Tanshinone IIA alone; FA: folic acid-treated mice followed by vehicle treatment; FA + TS: folic acid-treated mice subjected to Tanshinone IIA injection for 3 consecutive days.

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