Evaluation of Influence of Various Polymers on Dissolution and Phase Behavior of Carbamazepine-Succinic Acid Cocrystal in Matrix Tablets

Table 1

Composition of different CBZ-SUC tablets formulations.

Composition of matrix tablet	Code	Drug : polymer	Percent drug released after six hours
CBZ-SUC: HPMC	CSH-1	1 : 1	30 ± 2.5
	CSH-2	1 : 0.5	39 ± 1.2
	CSH-3	1 : 0.25	53 ± 2.7
CBZ-SUC: Soluplus	CSS-1	1 : 1	77 ± 3.5
	CSS-2	1 : 0.5	67 ± 2.6
	CSS-3	1 : 0.25	59 ± 5.1
CBZ-SUC: Kollidon VA 64	CSK-1	1 : 1	83 ± 3.2
	CSK-2	1 : 0.5	50 ± 4.1
	CSK-3	1 : 0.25	38 ± 2.4

250 mg of CBZ-SUC is equivalent to 200 mg pure CBZ.