Activity of BKM120 and BEZ235 against Lymphoma Cells

Figure 6

Western blots of cellular extracts from HUT78, GRANTA519, and WSU-NHL that were treated with the IC₅₀ of BKM120 and BEZ235 for 24 h. Cellular extracts were probed with antibodies against p-AKT (Ser473), total AKT (Ser473), p-mTOR (Ser2448), total mTOR, p-4EBP1 (Thr37/46), total 4EBP1, p-p70S6kinase (Thr421/Ser424), and total p70S6kinase. Densitometric quantification of bands normalized to the untreated control is shown below the immunoblot bands.