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BioMed Research International
Volume 2015, Article ID 871202, 11 pages
Research Article

Synthesis and Characterization of Biodegradable Polyurethane for Hypopharyngeal Tissue Engineering

1Lihuili Hospital, Ningbo University, 818 Fenghua Road, Ningbo 315211, China
2The Medical School, Ningbo University, 818 Fenghua Road, Ningbo 315211, China
3School of Chemical Engineering, Ningbo University of Technology, 201 Fenghua Road, Ningbo 315211, China

Received 3 November 2014; Revised 18 January 2015; Accepted 13 February 2015

Academic Editor: Esmaiel Jabbari

Copyright © 2015 Zhisen Shen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Biodegradable crosslinked polyurethane (cPU) was synthesized using polyethylene glycol (PEG), L-lactide (L-LA), and hexamethylene diisocyanate (HDI), with iron acetylacetonate (Fe(acac)3) as the catalyst and PEG as the extender. Chemical components of the obtained polymers were characterized by FTIR spectroscopy, 1H NMR spectra, and Gel Permeation Chromatography (GPC). The thermodynamic properties, mechanical behaviors, surface hydrophilicity, degradability, and cytotoxicity were tested via differential scanning calorimetry (DSC), tensile tests, contact angle measurements, and cell culture. The results show that the synthesized cPU possessed good flexibility with quite low glass transition temperature (, −22°C) and good wettability. Water uptake measured as high as 229.7 ± 18.7%. These properties make cPU a good candidate material for engineering soft tissues such as the hypopharynx. In vitro and in vivo tests showed that cPU has the ability to support the growth of human hypopharyngeal fibroblasts and angiogenesis was observed around cPU after it was implanted subcutaneously in SD rats.