Table 2: List of spots that differed significantly when RCMD patients were compared with a control group of healthy volunteers.

SpotProteinUniprot ACPeptidesFold

1Vinculin P1820650.00172.7

2Tubulin alpha-1C chain; tubulin alpha-1B chain Q9BQE3; P6836340.004782.6
Annexin A6 P08133 2

3Alpha-enolase P06733 80.026−2.5

4Alpha-enolase P06733 60.0345−2.4

5Cytosolic nonspecific dipeptidase Q96KP4 140.00179−2.3
Tubulin beta chain P07437 5

6Annexin A1 P04083 100.00387−2.4

7Leukotriene A-4 hydrolase P09960 120.0000401−2.1

8T-complex protein 1 subunit theta P50990 60.00287−1.7

9Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 30.01332.1

10Plastin-2P13796170.000467−3.3

11Protein S100-A9 P0670210.0259−2.0

12Neutral alpha-glucosidase ABQ1469730.012−2.0

13Leukocyte elastase inhibitor P3074080.0114−2.0

14Alpha-enolase P0673340.000782−2.0
Adenylosuccinate synthetase isozyme 2P305205
Rab GDP dissociation inhibitor beta P503953
C-terminal-binding protein 1Q133632

15Annexin A7 P2007330.00019−2.0
AdenosylhomocysteinaseP235263
Proliferation-associated protein 2G4 Q9UQ801

16Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 30.02471.9
T-complex protein 1 subunit beta P783712

17Vinculin P1820650.0002671.9

18Triosephosphate isomerase P6017450.000113−1.7

19Eukaryotic initiation factor 4A-IP6084260.000589−1.9
Heterogeneous nuclear ribonucleoprotein FP525974
Heterogeneous nuclear ribonucleoprotein QO605064
T-complex protein 1 subunit thetaP509903

20Plastin-2P13796140.00156−1.9

21Alpha-enolase P06733 70.00129−1.9

22Plastin-2P13796160.0363−1.9

23Proteasome subunit alpha type-6P6090040.000319−1.8
UPF0568 protein C14orf166 Q9Y2244
Hypoxanthine-guanine phosphoribosyltransferaseP004922

24Alpha-enolase P06733 60.01721.8

25Ubiquitin carboxyl-terminal hydrolase 5P4597450.00228−1.7

26Proteasome activator complex subunit 1Q0632320.00171.7
Coagulation factor XIII A chain P004882

27Heat shock cognate 71 kDa protein P1114240.00034−1.8
Rho-related GTP-binding protein RhoC P081342

2840S ribosomal protein SA P0886570.00126−1.8

29Triosephosphate isomerase P6017470.0217−1.8

30T-complex protein 1 subunit zeta P4022740.00972−1.8

31WD repeat-containing protein 1O7508390.0183−1.8

32Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 20.001521.7
Heterogeneous nuclear ribonucleoprotein KP619782
ADP-sugar pyrophosphatase Q9UKK92

33Coronin-1A P3114620.00433−1.7

3426S proteasome non-ATPase regulatory subunit 14O0048720.000458−1.7

35m7GpppX diphosphatase Q96C8640.00316−1.5
Transaldolase P378373

36Proliferation-associated protein 2G4 Q9UQ8030.000667−1.7
Annexin A1 P04083 2

37Macrophage-capping protein P4012130.0279−1.7

38Talin-1Q9Y49050.004971.7

39Heat shock 70 kDa protein 4P3493250.0282−1.7

40Plastin-2P13796170.0131−1.6

41Glutathione S-transferase PP0921160.000628−1.8

42Protein S100-A7 P3115120.00218−1.6

43Talin-1Q9Y49040.008041.6

44Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform P3015370.00245−1.6

45Ribonuclease inhibitor P1348930.0247−1.6

46Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 30.001811.6

47Tubulin beta-1 chain Q9H4B720.01441.6

48Vinculin P1820630.01041.6

49Annexin A5 P08758120.00129−1.8

50Proteasome activator complex subunit 2Q9UL4630.000338−1.6

51Annexin A6 P08133200.000508−2.6
Heat shock 70 kDa protein 1A/1BP081073
Heat shock 70 kDa protein 1-like P349312
Heat shock protein HSP 90-alpha P079002

52Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 20.000127−1.6
Glutathione S-transferase PP092113

53Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 20.03521.5

54Triosephosphate isomerase P6017420.00181−1.5

55Ras GTPase-activating-like protein IQGAP1 P46940130.0219−1.7

56Actin, cytoplasmic 1; Actin, cytoplasmic 2P60709; P63261 20.0191.5

57Rab GDP dissociation inhibitor beta P5039530.0336−1.5
26S proteasome non-ATPase regulatory subunit 11 O002312

58Rab GDP dissociation inhibitor beta P50395130.0000838−1.5
Alpha-enolase P06733 6
Adenylosuccinate synthetase isozyme 2P305205
Beta-centractin P420253

59Tubulin alpha-1C chain Q9BQE350.03931.5
Tubulin alpha-1A chain Q71U365
Tubulin alpha-4A chain P683664

60Alpha-enolase P06733 70.04591.5
Phosphoglycerate kinase 1P005588

61Lymphocyte-specific protein 1P3324120.00972−1.5
Secernin-1Q127653

62Eukaryotic translation initiation factor 3 subunit HO1537230.00335−1.5
T-complex protein 1 subunit eta Q998324

63L-Lactate dehydrogenase B chain P0719580.00156−1.5
Pyruvate kinase isozymes M1/M2P146185

646-PhosphogluconolactonaseO9533650.0029−1.5
Endoplasmic reticulum resident protein 29 P300404

65Pyruvate kinase isozymes M1/M2 P1461880.000801−1.7
Sorting nexin-6Q9UNH72

66Proteasome subunit beta type-3P4972030.00454−1.5
Triosephosphate isomerase P601745

67Pyruvate kinase isozymes M1/M2 P14618160.0219−1.5

6814-3-3 protein zeta/delta P63104 60.0053−1.6

694-trimethylaminobutyraldehyde dehydrogenase P4918920.0183−1.4
Caspase-1P294662

70Proteasome subunit beta type-4P2807020.000337−1.4

71Chloride intracellular channel protein 1O0029960.00012−1.7
Tumor protein D5O43399 2

72Major vault protein Q1476480.0122−1.7
Ubiquitin-like modifier-activating enzyme 1P223148

73Transitional endoplasmic reticulum ATPase P55072130.0132−1.8
Ras GTPase-activating-like protein IQGAP1 P469403

74Serum albumin P02768100.00454−1.7

75Heat shock protein beta-1P0479220.001871.5

76Vinculin P18206 60.00886−1.5

77Gelsolin P0639670.0459−2.1

78Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 50.02211.9
Annexin A1 P04083 3

79Tryptophan-tRNA ligase, cytoplasmic P2338170.00185−1.6

80Vinculin P18206 70.0369−1.7

81Proteasome activator complex subunit 1Q0632370.0328−1.5

82Cofilin-1P2352830.000586−1.7

83Endoplasmin P1462550.00491−2.6

84Alpha-enolase P0673340.0001662.4
Monoglyceride lipase Q996851

85Alpha-actinin-1P1281420.007772.4

86Heterogeneous nuclear ribonucleoprotein H2 P5579540.000792−2.3
Heterogeneous nuclear ribonucleoprotein HP319433

87Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 30.007522.3
Alpha-actinin-1P128142

88Delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, mitochondrialQ1301130.000218−2.2
Estradiol 17-beta-dehydrogenase 8Q925062

89Heterogeneous nuclear ribonucleoproteins A2/B1P2262630.000986−2.2

90Transitional endoplasmic reticulum ATPaseP5507250.00163−2.1

91Aconitate hydratase, mitochondrialQ9979870.000362−2.1
EndoplasminP146252

92EndoplasminP1462570.000319−2.0

93Heat shock 70 kDa protein 1A/1B P0810740.00155−2.0
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrialP105156
Stress-70 protein, mitochondrialP386463
Annexin A6P081333

94Heat shock protein 75 kDa, mitochondrialQ1293130.00144−2.0

9578 kDa glucose-regulated protein P11021170.0018−2.5
Protein disulfide-isomerase A4P136674
Endoplasmin P146252

96Endoplasmic reticulum resident protein 29 P3004060.00318−1.9
ATP synthase subunit gamma, mitochondrial P365422

97EndoplasminP1462570.0109−1.9

98Tropomyosin alpha-4 chain P6793640.007552.1

9978 kDa glucose-regulated proteinP1102170.00377−1.8

100EndoplasminP1462550.0108−1.8

10140S ribosomal protein SA P0886530.00000707−1.8
VimentinP086704

102F-actin-capping protein subunit beta P4775620.000949−1.8

10378 kDa glucose-regulated proteinP11021150.00946−2.1

104Superoxide dismutase [Cu-Zn]P0044110.001391.7
ATP synthase subunit alpha, mitochondrial P257051

105Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 40.001381.7

106F-actin-capping protein subunit alpha-1P5290720.002471.7

107Purine nucleoside phosphorylaseP0049120.00353−1.7
Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 1P048432

108Stress-70 protein, mitochondrialP38646100.00224−1.6
Heat shock cognate 71 kDa protein P111424

109Stress-70 protein, mitochondrialP3864620.01371.7

110Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 20.002011.7

111Delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, mitochondrialQ1301130.00338−1.7

11260 kDa heat shock protein, mitochondrial P1080960.003851.7
Integrin beta-3P051064
ATP synthase subunit beta, mitochondrial P065762

113Aldehyde dehydrogenase, mitochondrial P0509190.000949−1.7

114Heat shock cognate 71 kDa protein P1114280.0122−1.7
Stress-70 protein, mitochondrialP386464
EndoplasminP146254

115T-complex protein 1 subunit beta P7837150.0215−1.7

116MoesinP2603840.000902−1.6
T-complex protein 1 subunit zeta P783712

117Macrophage-capping proteinP4012120.0114−1.6

118Stress-70 protein, mitochondrialP38646130.0106−1.7
Annexin A6P081333

11960 kDa heat shock protein, mitochondrial P10809110.000211−1.6
Heterogeneous nuclear ribonucleoprotein KP619782

120Elongation factor Tu, mitochondrial P4941140.00392−1.5
Isocitrate dehydrogenase [NADP] cytoplasmicO758742

121Pre-mRNA-processing factor 19 Q9UMS420.00523−1.6

122Prohibitin P35232 90.0121−1.6
Annexin A2 P073556

12378 kDa glucose-regulated proteinP1102160.0216−1.6
ATP synthase subunit beta, mitochondrial P065764
Integrin alpha-IIb P085142

124DnaJ homolog subfamily B member 11 Q9UBS420.00315−1.6
Moesin P26038 2

125Protein disulfide-isomeraseP0723770.0422−1.6

126GelsolinP0639630.02941.5

12714-3-3 protein zeta/delta P6310450.03371.5
14-3-3 protein eta Q049172

12860 kDa heat shock protein, mitochondrial P10809180.00252−1.5

129Endoplasmin P1462540.0251−1.6

130Synaptosomal-associated protein 23 O0016130.02541.5

131Stress-induced-phosphoprotein 1P3194810.0329−1.5

132CalreticulinP2779720.00435−1.5

133UPF0568 protein C14orf166 Q9Y22440.0208−1.5

13460 kDa heat shock protein, mitochondrial P1080970.0004121.5
ATP synthase subunit beta, mitochondrial P065762
Integrin beta-3P051062

135Alpha-enolase P0673340.0357−1.5

136Myosin-9P3557950.01061.5

137Myosin regulatory light polypeptide 9P2484430.03251.7
Protein disulfide-isomerase A6 Q150842

138Endoplasmic reticulum resident protein 29P3004060.0104−1.5

139Peroxiredoxin-4Q1316220.0362−1.5

140Tyrosine-protein phosphatase nonreceptor type 6 P2935030.0319−1.5
Protein disulfide-isomerase A3 P301012

141Protein disulfide-isomerase A3 P3010120.0125−1.5

142PDZ and LIM domain protein 1O0015120.003061.5

143ATP synthase subunit beta, mitochondrial P06576180.00266−1.4
Protein disulfide-isomerase A6 Q150846
78 kDa glucose-regulated proteinP110214
Protein disulfide-isomerase P072372
VimentinP086702

144Plastin-2P13796150.000372−1.6

145Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 30.009051.5

146Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 40.01561.8

14760 kDa heat shock protein, mitochondrial P1080990.0181.5

148Filamin-AP2133340.0001232.6

149Filamin-AP2133330.001162.6

150Alpha-actinin-1P1281470.001042.4

151Ficolin-1O0060220.000967−2.4

152EzrinP1531130.0136−2.4

153Coronin-1A P3114610.00915−2.2

154Alpha-actinin-1P1281440.001092.2

155Fermitin family homolog 3Q86UX720.0002612.1

156Filamin-AP2133320.0005682.1

157Alpha-actinin-1P1281450.00172.0

158Filamin-AP2133320.01231.9

159Ficolin-1 O0060220.0221−1.8

160Alpha-actinin-1P1281450.0005161.6
Filamin-AP213332

16114-3-3 protein zeta/delta P6310430.0221.8

162Prohibitin P3523230.0414−1.8

163Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 20.01331.7

164Nucleoprotein TPR P1227010.009521.7

165Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 50.0371.7
Filamin-AP213333
Beta-parvin Q9HBI12

166Alpha-actinin-1P1281430.009691.7

167Filamin-AP2133320.01091.7

168Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 20.005292.8

169EzrinP1531120.0174−1.7

170Beta-actin-like protein 2 Q562R1 20.02261.6

171Filamin-AP2133320.009751.6

172Filamin-AP2133330.03191.6

173Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 20.02021.6

174Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 30.02071.6

175Myosin-9P3557920.02251.6

176Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 40.0009912.2

177Filamin-AP2133330.01311.5

178Filamin-AP2133350.0312.1
Actin, cytoplasmic 1; actin, cytoplasmic 2P60709; P63261 3