Identification of Gene Expression Pattern Related to Breast Cancer Survival Using Integrated TCGA Datasets and Genomic Tools

Figure 3

Different gene expression patterns of mitochondrial ribosome and cytosol ribosome. (a) The Kaplan-Meier survival curves of gene expression pattern of mitochondrial ribosome genes (MRPL13, MRPL18, MRPS23, MRPS25, and MRPS7) and cytosol ribosome genes (RPL13A, RPL3, RPS27, and RPS9). (b) A gene expression clustering heat map of the above 9 mitochondrial ribosome and cytosol ribosome genes in the TCGA breast cancer (red for high expression value and blue for low expression value). Genes with different expression level were clustered in cytosol and mitochondrion ribosome. The samples were also clustered into two groups (Cluster I and Cluster II) based on the expression value of these 9 genes. (c) The Kaplan-Meier survival curves of Cluster I and Cluster II samples show the difference of overall survival.