Improving the Understanding of Pathogenesis of Human Papillomavirus 16 via Mapping Protein-Protein Interaction Network

Figure 4

Characteristics of targeted human proteins. (a) The enrichment of targeted human proteins as a function of their degree was calculated. It indicated that hub proteins appeared to be primarily targeted. (b) Analogously, HPV16 tended to interact with bottleneck proteins. (c) values of Fisher’s exact tests indicated that HPV16 is highly prone to interact with hub proteins and bottleneck proteins. (d) Considering all set, most proteins have low pathway participation coefficients, which indicated that HPV16 reached into a breadth of signaling pathways. Such a result was shown by positive training set and predicted set.

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