Preoperative Neutrophil-to-Lymphocyte Ratio and Neutrophilia Are Independent Predictors of Recurrence in Patients with Localized Papillary Renal Cell Carcinoma

Table 4

Univariable and multivariable Cox regression models to predict RFS in 218 patients treated with nephrectomy with curative intent for pRCC.

Variables	Univariable	P value	Stepwise analyses	P value
	HR (95% CI)		HR (95% CI)
Age greater than 60	0.74 (0.31–1.79)	0.507
Gender (male versus female)	0.92 (0.34–2.54)	0.875
Symptoms at presentation (yes versus no)	2.07 (0.79–5.41)	0.138
Hypertension (yes versus no)	1.40 (0.56–3.46)	0.471
Diabetes mellitus (yes versus no)	0.43 (0.06–3.24)	0.414
pTNM stage
T (III versus II versus I)	2.43 (1.50–3.92)	<0.001
N1 versus pNx/0	5.82 (1.29–26.28)	0.022
TNM group (III versus II versus I)	2.62 (1.62–4.26)	<0.001	2.19 (1.31–3.64)	0.003
Grade (G3-4 versus G1-2)	3.24 (1.31–7.99)	0.011	—	—
pRCC type (type 2 versus 1)	3.07 (1.21–7.77)	0.018	—	—
Tumor necrosis (yes versus no)	3.10 (1.23–7.80)	0.016	2.55 (0.97–6.70)	0.057
ANC (≥5.3/nL versus <5.3/nL)	8.64 (2.39–31.15)	0.001	4.71 (1.04–21.35)	0.045
ALC (≥1.3/nL versus <1.3/nL)	0.43 (0.16–1.14)	0.089
NLR (≥3.6 versus <3.6)	5.27 (2.11–13.17)	<0.001	4.01 (1.26–12.73)	0.018