Alleviation of Kainic Acid-Induced Brain Barrier Dysfunction by 4-O-Methylhonokiol in In Vitro and In Vivo Models

Figure 5

Effect of MH, scavengers on the MDA levels in KA-treated hippocampal tissue homogenates. Male mice were grouped ( or 6/group) and pretreated (i.p. injection) with MH (5–20 mg/kg), scavengers such as trolox (50 mg/kg, i.p.) or DMTU (50 mg/kg, i.p.), or NaCl (0.9%). Fifty minutes after the MH or saline pretreatment, seizures in the KA, scavengers + KA, and MH + KA groups were induced by KA injection (10 mg/kg, i.p.); the mice in the control group received an equal volume of 0.9% NaCl. All data are presented as means ± SE. versus control group. versus KA group.

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