MUTYH Gene Polymorphisms as Risk Factors for Rheumatoid Arthritis
Table 2
Association between genotypic and allelic distributions of MUTYH gene polymorphisms and individuals with RA.
SNP database ID
RA number (%)
Controls number (%)
value/ value
Odds ratio (95% CI)
rs3219463
G/G
37 (19.3)
76 (39.6)
0.00006*/
0.41 (0.21–0.82)
G/A
129 (67.2)
94 (49.0)
0.00024*
1.16 (0.62–2.17)
A/A
26 (13.5)
22 (11.4)
1.00
G allele
203 (52.9)
246 (64.1)
0.0016*/
0.63 (0.47–0.84)
A allele
181 (47.1)
138 (35.9)
0.0064*
1.00
G/G + G/A
166 (86.5)
170 (88.5)
0.5371/
0.83 (0.45–1.52)
A/A
26 (13.5)
22 (11.5)
2.1496
1.00
G/G
37 (19.3)
76 (39.6)
0.00001*/
0.36 (0.23–0.58)
G/A + A/A
155 (80.7)
116 (60.4)
0.00006*
rs3219476
T/T
33 (17.2)
17 (8.9)
0.0009*/
3.81 (1.81–8.04)
T/G
132 (68.8)
122 (63.5)
0.0036*
2.12 (1.26–3.59)
G/G
27 (14.0)
53 (27.6)
1.00
T allele
198 (51.6)
156 (40.6)
0.0024*/
1.56 (1.17–2.07)
G allele
186 (48.4)
228 (59.4)
0.0096*
1.00
T/T + T/G
165 (86)
139 (72.4)
0.0011*/
2.33 (1.39–3.90)
G/G
27 (14.0)
53 (27.6)
0.0044*
1.00
T/T
33 (17.2)
17 (8.9)
0.013*/
2.17 (1.17–4.05)
T/G + G/G
159 (82.8)
178 (91.1)
0.0650
1.00
rs3219489
G/G
52 (27.1)
70 (36.5)
0.1383/
0.61 (0.33–1.13)
G/C
106 (55.2)
94 (49.0)
0.5532
0.93 (0.52–1.65)
C/C
34 (17.7)
28 (14.5)
1.00
G allele
210 (54.7)
234 (60.9)
0.0795/
0.77 (0.58–1.03)
C allele
174 (45.3)
150 (39.1)
0.3180
1.00
G/G + G/C
158 (82.3)
164 (85.5)
0.4053/
0.79 (0.46–1.37)
C/C
34 (17.7)
28 (14.5)
1.6212
1.00
G/G
52 (27.1)
70 (36.5)
0.0485*/
0.65 (0.42–1.00)
G/C + C/C
140 (72.9)
122 (63.5)
0.1940
1.00
rs3219493
G/G
164 (85.4)
161 (83.9)
0.671/
1.13 (0.65–1.97)
G/C
28 (14.6)
31 (16.1)
2.6840
1.00
C/C
0 (0)
0 (0)
G allele
356 (92.7)
353 (91.9)
0.6844/
1.12 (0.66–1.90)
C allele
28 (7.3)
31 (8.1)
2.7376
1.00
G/G
164 (85.4)
161 (83.9)
0.6712/
1.13 (0.65–1.97)
G/C + C/C
28 (14.6)
31 (16.1)
1.3424
1.00
95% CI: 95% confidence intervals. value of <0.05 was determined as statistically significant. The chi-square test was performed to obtain the value. value: value corrected by Bonferroni correction.
