Potential Inhibitors for Isocitrate Lyase of Mycobacterium tuberculosis and Non-M. tuberculosis: A Summary

Figure 1

The general scheme for tricarboxylic acid (TCA) cycle (blue bold arrows) and glyoxylate cycle (green arrows). Isocitrate lyase (ICL, circled in red) is the first enzyme involved in the glyoxylate cycle. Oxaloacetate might leave the cycle as the substrate of gluconeogenesis (red dash arrow).