Potential Inhibitors for Isocitrate Lyase of Mycobacterium tuberculosis and Non-M. tuberculosis: A Summary

Figure 2

The structure of Mycobacterium tuberculosis isocitrate lyase in ribbon representation. (a) ICL tetramer with each subunit is represented by different colors [5]. (b) ICL monomer with active site (in cyan color) in “open conformation” and (c) ICL monomer with active site (in cyan color) in “close conformation” substrates (succinate and glyoxylate) are bound in the active site with red CPK representation.

(a)

(b)

(c)