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BioMed Research International
Volume 2015, Article ID 896372, 10 pages
http://dx.doi.org/10.1155/2015/896372
Research Article

Orthostatic Intolerance Is Independent of the Degree of Autonomic Cardiovascular Adaptation after 60 Days of Head-Down Bed Rest

1Department of Cardiology, Beijing Friendship Hospital, China Capital Medical University, Beijing 100050, China
2Department of Cardiology, University Hospital Gasthuisberg, KU Leuven, 3000 Leuven, Belgium
3State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing 100094, China

Received 30 May 2015; Revised 12 August 2015; Accepted 19 August 2015

Academic Editor: Cristiana Corsi

Copyright © 2015 Jiexin Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. R. Hargens and D. E. Watenpaugh, “Cardiovascular adaptation to spaceflight,” Medicine and Science in Sports and Exercise, vol. 28, no. 8, pp. 977–982, 1996. View at Publisher · View at Google Scholar · View at Scopus
  2. F. Beckers, B. Verheyden, J. Liu, and A. E. Aubert, “Cardiovascular autonomic control after short-duration spaceflights,” Acta Astronautica, vol. 65, no. 5-6, pp. 804–812, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. F. Beckers, B. Verheyden, and A. Aubert, “Evolution of heart rate variability before, during and after spaceflight,” Journal of Gravitational Physiology, vol. 10, pp. 107–108, 2003. View at Google Scholar
  4. B. Verheyden, J. X. Liu, F. Beckers, and A. E. Aubert, “Adaptation of heart rate and blood pressure to short and long duration space missions,” Respiratory Physiology and Neurobiology, vol. 169, no. 1, pp. S13–S16, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. M. B. Sides, J. Vernikos, V. A. Convertino et al., “The Bellagio report: cardiovascular risks of spaceflight: Implications for the future of space travel,” Aviation Space and Environmental Medicine, vol. 76, no. 9, pp. 877–895, 2005. View at Google Scholar · View at Scopus
  6. R. J. White and M. Averner, “Humans in space,” Nature, vol. 409, no. 6823, pp. 1115–1118, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. L.-F. Zhang, “Vascular adaptation to microgravity: what have we learned?” Journal of Applied Physiology, vol. 91, no. 6, pp. 2415–2430, 2001. View at Google Scholar · View at Scopus
  8. J. C. Buckey, L. D. Lane, B. D. Levine et al., “Orthostatic intolerance after spaceflight,” Journal of Applied Physiology, vol. 81, no. 1, pp. 7–18, 1996. View at Google Scholar · View at Scopus
  9. A. Pavy-Le Traon, M. Heer, M. V. Narici, J. Rittweger, and J. Vernikos, “From space to Earth: advances in human physiology from 20 years of bed rest studies (1986–2006),” European Journal of Applied Physiology, vol. 101, no. 2, pp. 143–194, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Gharib, G. Gauquelin, J. M. Pequignot, G. Geelen, C. A. Bizollon, and A. Guell, “Early hormonal effects of head-down tilt (-10 degrees) in humans,” Aviation, Space, and Environmental Medicine, vol. 59, no. 7, pp. 624–629, 1988. View at Google Scholar
  11. J. E. Greenleaf, “Physiology of fluid and electrolyte responses during inactivity: water immersion and bed rest,” Medicine & Science in Sports & Exercise, vol. 16, no. 1, pp. 20–25, 1984. View at Google Scholar · View at Scopus
  12. D. Sigaudo, J. O. Fortrat, A. Maillet, and et al, “Comparison of a 4-day confinement and head-down tilt on endocrine response and cardiovascular variability in humans,” European Journal of Applied Physiology and Occupational Physiology, vol. 73, no. 1-2, pp. 28–37, 1996. View at Publisher · View at Google Scholar · View at Scopus
  13. L. B. Johansen, C. Gharib, A.-M. Allevard et al., “Haematocrit, plasma volume and noradrenaline in humans during simulated weightlessness for 42 days,” Clinical Physiology, vol. 17, no. 2, pp. 203–210, 1997. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Blanc, S. Normand, P. Ritz et al., “Energy and water metabolism, body composition, and hormonal changes induced by 42 days of enforced inactivity and simulated weightlessness,” Journal of Clinical Endocrinology and Metabolism, vol. 83, no. 12, pp. 4289–4297, 1998. View at Google Scholar · View at Scopus
  15. H. W. J. Robbe, L. J. M. Mulder, H. Rueddel, W. A. Langewitz, J. B. P. Veldman, and G. Mulder, “Assessment of baroreceptor reflex sensitivity by means of spectral analysis,” Hypertension, vol. 10, no. 5, pp. 538–543, 1987. View at Publisher · View at Google Scholar · View at Scopus
  16. R. L. Hughson, Y. Yamamoto, A. P. Blaber et al., “Effect of 28-day head-down bed rest with countermeasures on heart rate variability during LBNP,” Aviation Space and Environmental Medicine, vol. 65, no. 4, pp. 293–300, 1994. View at Google Scholar · View at Scopus
  17. A. Pavy-Le Traon, D. Sigaudo, P. Vasseur et al., “Cardiovascular responses to orthostatic tests after a 42-day head-down bed-rest,” European Journal of Applied Physiology and Occupational Physiology, vol. 77, no. 1-2, pp. 50–59, 1998. View at Publisher · View at Google Scholar · View at Scopus
  18. K.-I. Iwasaki, R. Zhang, J. H. Zuckerman, J. A. Pawelczyk, and B. D. Levine, “Effect of head-down-tilt bed rest and hypovolemia on dynamic regulation of heart rate and blood pressure,” The American Journal of Physiology—Regulatory Integrative and Comparative Physiology, vol. 279, no. 6, pp. R2189–R2199, 2000. View at Google Scholar · View at Scopus
  19. R. M. Baevsky, V. M. Baranov, I. I. Funtova et al., “Autonomic cardiovascular and respiratory control during prolonged spaceflights aboard the International Space Station,” Journal of Applied Physiology, vol. 103, no. 1, pp. 156–161, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. A. E. Aubert, D. Ramaekers, F. Beckers et al., “The analysis of heart rate variability in unrestrained rats. Validation of method and results,” Computer Methods and Programs in Biomedicine, vol. 60, no. 3, pp. 197–213, 1999. View at Publisher · View at Google Scholar · View at Scopus
  21. B. Verheyden, F. Beckers, K. Couckuyt, J. Liu, and A. E. Aubert, “Respiratory modulation of cardiovascular rhythms before and after short-duration human spaceflight,” Acta Physiologica, vol. 191, no. 4, pp. 297–308, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. B. E. Westerhof, J. Gisolf, W. J. Stok, K. H. Wesseling A, and J. M. Karemaker, “Time-domain cross-correlation baroreflex sensitivity: performance on the EUROBAVAR data set,” Journal of Hypertension, vol. 22, no. 7, pp. 1371–1380, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. K. H. Wesseling, J. R. C. Jansen, J. J. Settels, and J. J. Schreuder, “Computation of aortic flow from pressure in humans using a nonlinear, three-element model,” Journal of Applied Physiology, vol. 74, no. 5, pp. 2566–2573, 1993. View at Google Scholar · View at Scopus
  24. G. J. Langewouters, K. H. Wesseling, and W. J. A. Goedhard, “The static elastic properties of 45 human thoracic and 20 abdominal aortas in vitro and the parameters of a new model,” Journal of Biomechanics, vol. 17, no. 6, pp. 425–435, 1984. View at Publisher · View at Google Scholar · View at Scopus
  25. R. B. P. de Wilde, J. J. Schreuder, P. C. M. van den Berg, and J. R. C. Jansen, “An evaluation of cardiac output by five arterial pulse contour techniques during cardiac surgery,” Anaesthesia, vol. 62, no. 8, pp. 760–768, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. M. S. Pitt, P. Marshall, J. P. Diesch, and R. Hainsworth, “Cardiac output by Portapres,” Clinical Science, vol. 106, no. 4, pp. 407–412, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. N. van Dijk, I. G. J. M. de Bruin, J. Gisolf et al., “Hemodynamic effects of leg crossing and skeletal muscle tensing during free standing in patients with vasovagal syncope,” Journal of Applied Physiology, vol. 98, no. 2, pp. 584–590, 2005. View at Publisher · View at Google Scholar · View at Scopus
  28. M. P. M. Harms, K. H. Wesseling, F. Pott et al., “Continuous stroke volume monitoring by modelling flow from non-invasive measurement of arterial pressure in humans under orthostatic stress,” Clinical Science, vol. 97, no. 3, pp. 291–301, 1999. View at Publisher · View at Google Scholar · View at Scopus
  29. J. J. van Lieshout, K. Toska, E. J. van Lieshout, M. Eriksen, L. Walløe, and K. H. Wesseling, “Beat-to-beat noninvasive stroke volume from arterial pressure and Doppler ultrasound,” European Journal of Applied Physiology, vol. 90, no. 1-2, pp. 131–137, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. W. T. Jellema, K. H. Wesseling, A. B. J. Groeneveld, C. P. Stoutenbeek, L. G. Thijs, and J. J. Van Lieshout, “Continuous cardiac output in septic shock by simulating a model of the aortic input impedance: a comparison with bolus injection thermodilution,” Anesthesiology, vol. 90, no. 5, pp. 1317–1328, 1999. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Brignole, P. Alboni, D. Benditt et al., “Guidelines on management (diagnosis and treatment) of syncope,” European Heart Journal, vol. 22, no. 15, pp. 1256–1306, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. B. Verheyden, H. Ector, A. E. Aubert, and T. Reybrouck, “Tilt training increases the vasoconstrictor reserve in patients with neurally mediated syncope evoked by head-up tilt testing,” European Heart Journal, vol. 29, no. 12, pp. 1523–1530, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. B. Verheyden, J. X. Liu, N. van Dijk et al., “Steep fall in cardiac output is main determinant of hypotension during drug-free and nitroglycerine-induced orthostatic vasovagal syncope,” Heart Rhythm, vol. 5, no. 12, pp. 1695–1701, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Kamiya, S. Iwase, H. Kitazawa, and T. Mano, “Muscle sympathetic nerve activity (MSNA) after 120 days of 6 degrees head-down bed rest (HDBR),” Environmental Medicine, vol. 43, no. 2, pp. 150–152, 1999. View at Google Scholar · View at Scopus
  35. K. Hirayanagi, A. Kamiya, S. Iwase et al., “Autonomic cardiovascular changes during and after 14 days of head-down bed rest,” Autonomic Neuroscience: Basic and Clinical, vol. 110, no. 2, pp. 121–128, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. G. K. Prisk, H. J. B. Guy, A. R. Elliott, R. A. Deutschman III, and J. B. West, “Pulmonary diffusing-capacity, capillary blood-volume, and cardiac-output during sustained microgravity,” Journal of Applied Physiology, vol. 75, no. 1, pp. 15–26, 1993. View at Google Scholar · View at Scopus
  37. A. R. Elliott, G. K. Prisk, H. J. B. Guy, and J. B. West, “Lung volumes during sustained microgravity on spacelab SLS-1,” Journal of Applied Physiology, vol. 77, no. 4, pp. 2005–2014, 1994. View at Google Scholar · View at Scopus
  38. A. Pavy-Le Traon, F. Louisy, P. Vasseur-Clausen, A. Güell, and C. Gharib, “Contributory factors to orthostatic intolerance after simulated weightlessness,” Clinical Physiology, vol. 19, no. 5, pp. 360–368, 1999. View at Publisher · View at Google Scholar · View at Scopus
  39. V. A. Convertino, D. F. Doerr, and S. L. Stein, “Changes in size and compliance of the calf after 30 days of simulated microgravity,” Journal of Applied Physiology, vol. 66, no. 3, pp. 1509–1512, 1989. View at Google Scholar · View at Scopus
  40. G. C. Butler, H. Xing, D. R. Northey, and R. L. Hughson, “Reduced orthostatic tolerance following 4 h head-down tilt,” European Journal of Applied Physiology and Occupational Physiology, vol. 62, no. 1, pp. 26–30, 1991. View at Publisher · View at Google Scholar · View at Scopus
  41. J. Gisolf, B. E. Westerhof, N. van Dijk, K. H. Wesseling, W. Wieling, and J. M. Karemaker, “Sublingual nitroglycerin used in routine tilt testing provokes a cardiac output-mediated vasovagal response,” Journal of the American College of Cardiology, vol. 44, no. 3, pp. 588–593, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. P. Arbeille, P. Kerbeci, D. Greaves, S. Schneider, A. Hargens, and R. Hughson, “Arterial and venous response to Tilt with LBNP test after a 60 day HDT bedrest (WISE study),” Journal of Gravitational Physiology, vol. 14, no. 1, pp. 47–48, 2007. View at Google Scholar · View at Scopus
  43. J. M. Fritsch, J. B. Charles, B. S. Bennett, M. M. Jones, and D. L. Eckberg, “Short-duration spaceflight impairs human carotid baroreceptor-cardiac reflex responses,” Journal of Applied Physiology, vol. 73, no. 2, pp. 664–671, 1992. View at Google Scholar · View at Scopus
  44. J. M. Fritsch-Yelle, J. B. Charles, M. M. Jones, L. A. Beightol, and D. L. Eckberg, “Spaceflight alters autonomic regulation of arterial pressure in humans,” Journal of Applied Physiology, vol. 77, no. 4, pp. 1776–1783, 1994. View at Google Scholar · View at Scopus
  45. W. H. Cooke, J. E. Ames IV, A. A. Crossman et al., “Nine months in space: effects on human autonomic cardiovascular regulation,” Journal of Applied Physiology, vol. 89, no. 3, pp. 1039–1045, 2000. View at Google Scholar · View at Scopus
  46. J. M. Fritsch-Yelle, J. B. Charles, M. M. Jones, and M. L. Wood, “Microgravity decreases heart rate and arterial pressure in humans,” Journal of Applied Physiology, vol. 80, no. 3, pp. 910–914, 1996. View at Google Scholar · View at Scopus
  47. A. L. Goldberger, M. W. Bungo, R. M. Baevsky et al., “Heart rate dynamics during long-term space flight: report on Mir cosmonauts,” American Heart Journal, vol. 128, no. 1, pp. 202–204, 1994. View at Publisher · View at Google Scholar · View at Scopus
  48. J. C. Buckey Jr., F. A. Gaffney, L. D. Lane et al., “Central venous pressure in space,” Journal of Applied Physiology, vol. 81, no. 1, pp. 19–25, 1996. View at Google Scholar · View at Scopus
  49. N. Foldager, T. A. E. Andersen, F. B. Jessen et al., “Central venous pressure in humans during microgravity,” Journal of Applied Physiology, vol. 81, no. 1, pp. 408–412, 1996. View at Google Scholar · View at Scopus
  50. R. Videbaek and P. Norsk, “Atrial distension in humans during microgravity induced by parabolic flights,” Journal of Applied Physiology, vol. 83, no. 6, pp. 1862–1866, 1997. View at Google Scholar · View at Scopus