The Roles of Hedgehog Signaling in Upper Lip Formation

Figure 1

The growth of facial processes in mouse embryos shown by whole mount nuclear fluorescent imaging. ((A)–(E)) Oblique views of the facial development of mouse embryos from E10 to E12.0. ((F)–(J)) The same heads were captured from the ventral side of the head with the mandible removed. (K) The representative phenotype of cleft lip, which was induced by whole embryo culture. The red arrowheads show the position where the facial processes fuse. (L) Cartoon sequence of growing nasal processes at each stage. Black arrow shows the direction of processes growth and folding. MNP: medial nasal process, LNP: lateral nasal process, MXP: maxillary process, and Mn; mandible.