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BioMed Research International
Volume 2015, Article ID 901303, 11 pages
Research Article

Deciphering the Correlation between Breast Tumor Samples and Cell Lines by Integrating Copy Number Changes and Gene Expression Profiles

Department of Central Laboratory, Shanghai Tenth People’s Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China

Received 28 November 2014; Revised 16 January 2015; Accepted 26 January 2015

Academic Editor: Xiao Chang

Copyright © 2015 Yi Sun and Qi Liu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The gene expression pattern of ER, PR, HER2 and the global copy-number pattern of the breast tumor samples are given in Supplementary figure 1 and Supplementary figure 2. The numbers of over-expressed/underexpressed genes for each tumor groups as well as the overlapped genes of them are shown in Supplementary figure 3 and Supplementary figure 4. The copy-number pattern for the breast cancer cell lines is shown in Supplementary figure 5. The 2,426 genes with CNVs and the 4,843 differ-entially expressed genes (DEGs) for all groups of tumor samples are listed in Supplementary table 1 and Supplementary table 2. The 384 individual genes showed copy number change associated with alteration in their expression for all tumor sample groups are listed in Supplementary table 3. The cor-relation between all the cancer cell lines in CCLE and breast tumor sample groups using copy-number information or gene expression profiles are given in Supplementary table 4 and Supplementary table 5.

  1. Supplementary Material