Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 901590, 8 pages
http://dx.doi.org/10.1155/2015/901590
Research Article

The Effect of Bicarbonate Administration via Continuous Venovenous Hemofiltration on Acid-Base Parameters in Ventilated Patients

1Division of Nephrology, Department of Medicine, Massachusetts General Hospital, 7 Whittier Place, Suite 106, Boston, MA 02114, USA
2Division of Nephrology and Hypertension, Department of Medicine and Genetics, UNC School of Medicine, UNC Kidney Center, 7024 Burnett-Womack, CB No. 7155, Chapel Hill, NC 27599-7155, USA
3Renal Division, Department of Medicine, Brigham and Women’s Hospital, 75 Francis Street, MRB4, Boston, MA 02115, USA

Received 2 October 2014; Revised 8 December 2014; Accepted 22 December 2014

Academic Editor: Boris Jung

Copyright © 2015 Andrew S. Allegretti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Uchino, J. A. Kellum, R. Bellomo et al., “Acute renal failure in critically ill patients: a multinational, multicenter study,” Journal of the American Medical Association, vol. 294, no. 7, pp. 813–818, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  2. B. Jung, T. Rimmele, C. Le Goff et al., “Severe metabolic or mixed acidemia on intensive care unit admission: incidence, prognosis and administration of buffer therapy. A prospective, multiple-center study,” Critical Care, vol. 15, article R238, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. T. Naka and R. Bellomo, “Bench-to-bedside review: treating acid-base abnormalities in the intensive care unit—the role of renal replacement therapy,” Critical Care, vol. 8, no. 2, pp. 108–114, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. H. Khosravani, R. Shahpori, H. T. Thomas, A. W. Kirkpatrick, and K. B. Laupland, “Occurrence and adverse effect on outcome of hyperlactatemia in the critically ill,” Critical Care, vol. 13, no. 3, article R90, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. J. A. Kraut and I. Kurtz, “Use of base in the treatment of severe acidemic states,” American Journal of Kidney Diseases, vol. 38, no. 4, pp. 703–727, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. S. Sabatini and N. A. Kurtzman, “Bicarbonate therapy in severe metabolic acidosis,” Journal of the American Society of Nephrology, vol. 20, no. 4, pp. 692–695, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. J. A. Kraut and I. Kurtz, “Use of base in the treatment of acute severe organic acidosis by nephrologists and critical care physicians: results of an online survey,” Clinical and Experimental Nephrology, vol. 10, no. 2, pp. 111–117, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. A. I. Arieff, W. Leach, R. Park, and V. C. Lazarowitz, “Systemic effects of NaHCO3 in experimental lactic acidosis in dogs,” The American Journal of Physiology, vol. 242, no. 6, pp. F586–F591, 1982. View at Google Scholar · View at Scopus
  9. F. A. Halperin, S. Cheema-Dhadli, C. B. Chen, and M. L. Halperin, “Alkali therapy extends the period of survival during hypoxia: studies in rats,” American Journal of Physiology: Regulatory Integrative and Comparative Physiology, vol. 271, no. 2, pp. R381–R387, 1996. View at Google Scholar · View at Scopus
  10. D. J. Cooper, K. R. Walley, B. R. Wiggs, and J. A. Russell, “Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis. A prospective, controlled clinical study,” Annals of Internal Medicine, vol. 112, no. 7, pp. 492–498, 1990. View at Publisher · View at Google Scholar · View at Scopus
  11. J. A. Kraut and N. E. Madias, “Treatment of acute metabolic acidosis: a pathophysiologic approach,” Nature Reviews Nephrology, vol. 8, no. 10, pp. 589–601, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. J. A. Mattar, M. H. Weil, H. Shubin, and L. Stein, “Cardiac arrest in the critically ill. II. Hyperosmolal states following cardiac arrest,” The American Journal of Medicine, vol. 56, no. 2, pp. 162–168, 1974. View at Publisher · View at Google Scholar · View at Scopus
  13. J. S. Huseby and D. G. Gumprecht, “Hemodynamic effects of rapid bolus hypertonic sodium bicarbonate,” Chest, vol. 79, no. 5, pp. 552–554, 1981. View at Publisher · View at Google Scholar · View at Scopus
  14. J. A. Bettice, “Effect of hypocapnia on intracellular pH during metabolic acidosis,” Respiration Physiology, vol. 38, no. 3, pp. 257–266, 1979. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Levraut, C. Giunti, J.-P. Ciebiera et al., “Initial effect of sodium bicarbonate on intracellular pH depends on the extracellular nonbicarbonate buffering capacity,” Critical Care Medicine, vol. 29, no. 5, pp. 1033–1039, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. J. I. Shapiro, N. Elkins, J. Logan, L. B. Ferstenberg, and J. E. Repine, “Effects of sodium bicarbonate, disodium carbonate, and a sodium bicarbonate/carbonate mixture on the PCO2 of blood in a closed system,” The Journal of Laboratory and Clinical Medicine, vol. 126, no. 1, pp. 65–69, 1995. View at Google Scholar · View at Scopus
  17. R. L. Bishop and M. L. Weisfeldt, “Sodium bicarbonate administration during cardiac arrest. Effect on arterial pH, Pco2, and osmolality,” The Journal of the American Medical Association, vol. 235, no. 5, pp. 506–509, 1976. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Mathieu, R. Neviere, V. Billard, M. Fleyfel, and F. Wattel, “Effects of bicarbonate therapy on hemodynamics and tissue oxygenation in patients with lactic acidosis: A prospective, controlled clinical study,” Critical Care Medicine, vol. 19, no. 11, pp. 1352–1356, 1991. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Tolwani, “Continuous renal-replacement therapy for acute kidney injury,” The New England Journal of Medicine, vol. 367, no. 26, pp. 2505–2514, 2012. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  20. H. Morimatsu, S. Uchino, R. Bellomo, and C. Ronco, “Continuous renal replacement therapy: does technique influence electrolyte and bicarbonate control?” International Journal of Artificial Organs, vol. 26, no. 4, pp. 289–296, 2003. View at Google Scholar · View at Scopus
  21. J. Rocktäschel, H. Morimatsu, S. Uchino, C. Ronco, and R. Bellomo, “Impact of continuous veno-venous hemofiltration on acid-base balance,” International Journal of Artificial Organs, vol. 26, no. 1, pp. 19–25, 2003. View at Google Scholar · View at Scopus
  22. A. Davenport, “Anionic bases for continuous forms of renal replacement therapy (CCRT) in the ICU,” Intensive Care Medicine, vol. 25, no. 11, pp. 1209–1211, 1999. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Davenport, E. J. Will, and A. M. Davison, “Hyperlactataemia and metabolic acidosis during haemofiltration using lactate-buffered fluids,” Nephron, vol. 59, no. 3, pp. 461–465, 1991. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Davenport, D. P. Worth, and E. J. Will, “Hypochloraemic alkalosis after high-flux continuous haemofiltration and continuous arteriovenous haemofiltration with dialysis,” The Lancet, vol. 1, no. 8586, p. 658, 1988. View at Google Scholar · View at Scopus
  25. P. Heering, K. Ivens, O. Thümer et al., “The use of different buffers during continuous hemofiltration in critically ill patients with acute renal failure,” Intensive Care Medicine, vol. 25, no. 11, pp. 1244–1251, 1999. View at Publisher · View at Google Scholar · View at Scopus
  26. P. Heering, K. Ivens, O. Thümer, M. Brause, and B. Grabensee, “Acid-base balance and substitution fluid during continuous hemofiltration,” Kidney International, vol. 56, no. 72, pp. S37–S40, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. P. J. Hilton, J. Taylor, L. G. Forni, and D. F. Treacher, “Bicarbonate-based haemofiltration in the management of acute renal failure with lactic acidosis,” Quarterly Journal of Medicine, vol. 91, no. 4, pp. 279–283, 1998. View at Publisher · View at Google Scholar · View at Scopus
  28. A. N. Thomas, J. M. Guy, R. Kishen, I. F. Geraghty, B. J. M. Bowles, and P. Vadgama, “Comparison of lactate and bicarbonate buffered haemofiltration fluids: use in critically ill patients,” Nephrology Dialysis Transplantation, vol. 12, no. 6, pp. 1212–1217, 1997. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Symreng, M. J. Flanigan, and V. S. Lim, “Ventilatory and metabolic changes during high efficiency hemodialysis,” Kidney International, vol. 41, no. 4, pp. 1064–1069, 1992. View at Publisher · View at Google Scholar · View at Scopus
  30. H. K. Tan, S. Uchino, and R. Bellomo, “The acid-base effects of continuous hemofiltration with lactate or bicarbonate buffered replacement fluids,” International Journal of Artificial Organs, vol. 26, no. 6, pp. 477–483, 2003. View at Google Scholar · View at Scopus
  31. J.-J. Wagner, J. R. Bedarf, M. Russ et al., “A dverse influence of mixed acidemia on the biocompatibility of continuous veno-venous hemofiltration with respect to the lungs,” Artificial Organs, vol. 37, no. 12, pp. 1049–1058, 2013. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  32. F. L. Ferreira, D. P. Bota, A. Bross, C. Mélot, and J. L. Vincent, “Serial evaluation of the SOFA score to predict outcome in critically ill patients,” The Journal of the American Medical Association, vol. 286, no. 14, pp. 1754–1758, 2001. View at Publisher · View at Google Scholar · View at Scopus