The Effect of Bicarbonate Administration via Continuous Venovenous Hemofiltration on Acid-Base Parameters in Ventilated Patients
Table 3
Acid-base parameters and electrolytesa.
Hour 0
Hour 8
Hour 16
Hour 24
Hour 36
Hour 48
Hour 60
Hour 72
Hour 96
pH
7.32 ± 0.12
7.37 ± 0.08
7.37 ± 0.10
7.37 ± 0.08
7.39 ± 0.09
7.37 ± 0.08
7.38 ± 0.07
7.38 ± 0.07
7.37 ± 0.11
(n = 18)
(n = 18)
(n = 18)
(n = 18)
(n = 19)
(n = 17)
(n = 18)
(n = 18)
(n = 17)
CO2 (mmHg)
42.0 ± 14.6
37.3 ± 12.6
38.1 ± 9.7
39.9 ± 10.3
40.1 ± 11.6
39.4 ± 11.6
40.6 ± 10.3
42.2 ± 10.2
43.8 ± 16.1
(n = 18)
(n = 18)
(n = 18)
(n = 18)
(n = 19)
(n = 17)
(n = 18)
(n = 18)
(n = 17)
HCO3 (mmol/L)b
19.8 ± 5.1
20.1 ± 5.1
19.7 ± 4.2
22.3 ± 3.9
22.8 ± 3.7
23.1 ± 3.2
22.8 ± 3.5
23.3 ± 2.4
23.2 ± 3.8
(n = 19)
(n = 18)
(n = 18)
(n = 18)
(n = 19)
(n = 17)
(n = 18)
(n = 16)
(n = 16)
Base excess (mmol/L)
−5.2 ± 6.5
−4.2 ± 5.4
−3.9 ± 5.4
−3.3 ± 3.6
−2.2 ± 3.0
−2.3 ± 2.7
−1.8 ± 3.3
−1.2 ± 2.6
−1.4 ± 3.3
(n = 18)
(n = 18)
(n = 18)
(n = 18)
(n = 19)
(n = 17)
(n = 18)
(n = 18)
(n = 17)
Sodium (mmol/L)
132.7 ± 6.5
132.8 ± 5.1
132.5 ± 5.6
132.5 ± 5.9
132.1 ± 3.9
132.1 ± 3.9
132.1 ± 4.2
132.4 ± 4.1
131.1 ± 3.8
(n = 19)
(n = 18)
(n = 18)
(n = 18)
(n = 19)
(n = 17)
(n = 18)
(n = 16)
(n = 16)
Potassium (mmol/L)
4.9 ± 1.0
4.6 ± 0.8
4.6 ± 0.7
4.6 ± 0.7
4.5 ± 0.6
4.5 ± 0.8
4.4 ± 0.4
4.3 ± 0.5
4.5 ± 0.5
(n = 19)
(n = 19)
(n = 18)
(n = 19)
(n = 19)
(n = 19)
(n = 18)
(n = 17)
(n = 16)
Chloride (mmol/L)
96.4 ± 6.2
97.2 ± 5.7
97.4 ± 4.5
97.3 ± 5.4
98.5 ± 4.6
99.2 ± 3.5
98.2 ± 4.1
99.3 ± 3.7
98.8 ± 4.0
(n = 19)
(n = 18)
(n = 18)
(n = 18)
(n = 19)
(n = 17)
(n = 18)
(n = 16)
(n = 16)
Ionized calcium (mg/dL)
1.03 ± 0.1
1.08 ± 0.3
1.05 ± 0.1
1.04 ± 0.1
1.03 ± 0.1
1.08 ± 0.1
1.09 ± 0.1
1.11 ± 0.1
1.11 ± 0.1
(n = 19)
(n = 16)
(n = 17)
(n = 19)
(n = 18)
(n = 16)
(n = 18)
(n = 16)
(n = 15)
BUN (mg/dL)
68.4 ± 35.8
60.2 ± 33.2
51.8 ± 27.1
45.4 ± 22.5
40.1 ± 20.2
37.5 ± 18.9
34.1 ± 16.4
30.5 ± 15.2
29.4 ± 14.6
(n = 19)
(n = 18)
(n = 18)
(n = 18)
(n = 19)
(n = 17)
(n = 18)
(n = 16)
(n = 16)
Creatinine (mg/dL)
3.9 ± 1.2
3.5 ± 1.2
3.1 ± 1.1
2.8 ± 1.0
2.4 ± 1.0
2.3 ± 0.8
2.0 ± 0.7
2.0 ± 0.7
1.7 ± 0.7
(n = 19)
(n = 18)
(n = 18)
(n = 18)
(n = 19)
(n = 17)
(n = 18)
(n = 16)
(n = 16)
Values presented as mean ± standard deviation.
bDrawn from venous chemistry panel. CO2: partial arterial pressure of carbon dioxide, HCO3: bicarbonate, and BUN: blood urea nitrogen.