Clinical Usefulness of Immunohistochemical Staining of p57kip2 for the Differential Diagnosis of Complete Mole
Table 1
Fourteen equivocal cases subjected to polymer-based p57kip2 immunohistochemistry for differentiation between complete and partial mole or hydropic abortion.
Case/patient
Age (yr)
G-P-A
Clinical Dx*
hCG mIU/mL before evacuation
Histopathologic Dx
p57kip2 staining
Final Dx
1
40
1-0-1
7 weeks
6700
Hydropic/partial
+
Hydropic/partial
2**
30
3-3-0
7 weeks
4780
Partial/complete
−
Complete mole
3
40
2-2-0
7 weeks
49100
Partial/complete
+
Partial
4
27
3-2-1
8 weeks
83100
Partial/complete
+
Partial
5**†
48
4-2-2
6 weeks
6590
partial/complete
−
Complete mole
6**
30
3-1-2
7 weeks
28500
Partial/complete
−
Complete mole
7
27
1-1-0
8 weeks
91700
Hydropic/partial
+
Hydropic/partial
8
44
3-1-2
7 weeks
4670
Hydropic/partial
+
Hydropic/partial
9**
27
1-1-0
6 weeks
31200
Partial/complete
−
Complete mole
10
34
2-1-1
7 weeks
7800
Partial/complete
+
Partial
11
34
2-1-1
8 weeks
4400
Partial/complete
+
Partial
12
33
0-0-0
5 weeks
4600
Partial/complete
+
Partial
13
32
1-1-0
6 weeks
6800
Hydropic/partial
+
Hydropic/partial
14
36
3-2-1
6 weeks
5200
Hydropic/partial
+
Hydropic/partial
G-P-A, gravida/para/abortus; hCG, human chorionic gonadotropin; dilation and curettage; Dx, diagnosis. *All diagnosed clinically as blighted ovum; **clearly differentiated as complete hydatidiform mole by polymer-based immunohistochemistry for p57kip2; †hCG elevated to 8740, persistent trophoblastic disease, treated by single-agent chemotherapy.
S. SASAKI 2012.