Assessment of Functional Characteristics of Amnestic Mild Cognitive Impairment and Alzheimer’s Disease Using Various Methods of Resting-State FMRI Analysis

Figure 5

Brain regions exhibiting significant differences in the global brain connectivity (GBC) index. (a) Brain regions showed significant differences in the GBC index between healthy subjects and patients with aMCI and patients with AD ( (uncorrected , , 864 mm³, and AlphaSim corrected)). The results of the post hoc two-sample -tests between pairs of the healthy subjects and patients with AD and aMCI were as follows: significant differences in the brain regions were found (b) in patients with aMCI compared with healthy subjects, (c) in patients with AD compared with patients with aMCI, and (d) in patients with AD compared with healthy subjects (). The images are oriented with the anterior side placed at the top and the left side placed to the right.