Assessment of Functional Characteristics of Amnestic Mild Cognitive Impairment and Alzheimer’s Disease Using Various Methods of Resting-State FMRI Analysis
Table 2
Brain regions with significant differences in regional homogeneity index between healthy subjects and patients with aMCI or AD.
Brain regions
R/L
Coordinates (mm)
Peak values
Voxels
Healthy subjects versus aMCI versus AD
Middle temporal gyrus
L
−40
−60
8
19.59
3286
Middle temporal gyrus
R
44
−58
4
16.07
848
ACC
L
−2
16
28
23.40
736
Middle temporal gyrus
R
32
−68
30
15.98
690
Postcentral gyrus
L
−36
−30
42
16.36
469
Postcentral gyrus
R
38
−32
56
15.62
301
Insula
R
38
16
6
15.86
272
ACC
R
14
28
28
16.29
224
Precuneus
R
2
−78
28
11.92
212
Middle occipital gyrus
R
34
−76
−6
12.02
186
IPL
L
−58
−26
28
14.60
171
Postcentral gyrus
R
52
−18
32
12.40
167
PCC
R
22
−58
18
16.72
162
Precuneus
L
−18
−68
16
13.20
160
Cingulate gyrus
L
−4
−34
30
11.61
160
Inferior frontal gyrus
L
−26
6
6
15.43
144
ACC: anterior cingulate cortex, IPL: inferior parietal gyrus, and PCC: posterior cingulate cortex. Threshold: corrected < 0.05 (uncorrected individual voxel height threshold of < 0.01, > 4.776 with a minimum cluster size of 864 mm3).
