Assessment of Functional Characteristics of Amnestic Mild Cognitive Impairment and Alzheimer’s Disease Using Various Methods of Resting-State FMRI Analysis
Table 4
Brain regions with significant differences in fractional ALFF (fALFF) index between healthy subjects and patients with aMCI or AD.
Brain regions
R/L
Coordinates (mm)
Peak values
Voxels
Healthy subjects versus aMCI versus AD
Inferior parietal lobule
L
−54
−56
48
15.82
1654
PCC
L
−8
−60
12
13.17
743
Fusiform gyrus
R
38
−40
−8
16.58
461
Cerebellum
L
−24
−12
−36
12.98
422
Middle frontal gyrus
L
−40
38
18
13.38
416
Inferior parietal lobule
R
50
−40
46
9.66
246
Precuneus
R
14
−68
40
9.14
205
Middle frontal gyrus
R
10
58
22
12.49
201
Precentral gyrus
L
−52
2
8
13.33
200
Postcentral gyrus
L
−48
−30
36
12.26
195
Inferior frontal gyrus
R
48
22
16
12.23
167
Middle temporal gyrus
R
58
6
−22
13.34
164
Superior temporal gyrus
R
50
−42
16
8.70
163
Parahippocampal gyrus
R
34
−12
−28
10.76
146
Cuneus
R
14
−68
6
12.11
140
Medial frontal gyrus
L
−2
52
−4
9.09
134
PCC: posterior cingulate cortex. Threshold: corrected < 0.05 (uncorrected individual voxel height threshold of < 0.01, > 4.776 with a minimum cluster size of 864 mm3).
