Assessment of Functional Characteristics of Amnestic Mild Cognitive Impairment and Alzheimer’s Disease Using Various Methods of Resting-State FMRI Analysis

Table 5

Brain regions with significant differences in global brain connectivity (GBC) index between healthy subjects and patients with aMCI or AD.

Brain regions	R/L	Coordinates; (mm)			Peak; values	Voxels
		Healthy subjects versus aMCI versus AD
ACC	L	−2	12	28	15.36	763
Superior temporal gyrus	L	−68	−24	6	11.24	282
Cerebellum	L	−28	−46	−48	10.10	253
Postcentral gyrus	L	−20	−52	66	8.41	208
Superior temporal gyrus	L	−38	−58	12	16.27	170
Superior temporal gyrus	L	−50	−42	14	9.37	159
Parahippocampal gyrus	L	−38	−26	−12	8.74	153
Cingulate gyrus	L	−12	−14	40	14.49	145
Transverse temporal gyrus	L	−50	−24	12	7.29	143
Superior temporal gyrus	R	46	8	−16	12.21	127

ACC: anterior cingulate cortex. Threshold: corrected < 0.05 (uncorrected individual voxel height threshold of < 0.01, > 4.776 with a minimum cluster size of 864 mm³).