Assessment of Functional Characteristics of Amnestic Mild Cognitive Impairment and Alzheimer’s Disease Using Various Methods of Resting-State FMRI Analysis

Table 6

Results of post hoc two-sample -tests between every pair of the healthy subjects and patients with AD and aMCI groups in ReHo approach.

Brain regions	R/L	Coordinates; (mm)			Peak; value	Voxels
		Healthy subject versus aMCI
Superior parietal lobule	L	−18	−76	56	4.27	531
Cingulate gyrus	L	−4	−4	48	5.12	381
Precuneus	R	26	−62	50	5.59	284
Middle occipital gyrus	L	−38	−66	−12	5.39	279
Precentral gyrus	L	−40	−18	42	4.88	270
Superior temporal gyrus	L	−50	−2	2	5.25	266
Superior temporal gyrus	L	−54	−42	16	4.83	250
Precentral gyrus	R	40	−24	60	4.98	235
Middle occipital gyrus	L	−52	−72	2	5.07	220
Cingulate gyrus	R	8	24	38	5.19	184
Middle temporal gyrus	R	34	−70	26	4.27	177
Postcentral gyrus	R	52	−18	32	4.94	149
Insula	R	38	16	6	4.63	146
aMCI versus AD; No result
Healthy subject versus AD
Middle temporal gyrus	L	−40	−60	8	6.22	1460
Middle temporal gyrus	R	44	−58	4	5.44	735
ACC	L	−2	16	28	6.49	551
Middle temporal gyrus	L	−50	−20	−8	5.31	399
Middle temporal gyrus	R	32	−68	30	5.21	329
Precentral gyrus	R	36	−24	54	4.97	197
Superior parietal lobule	L	−34	−56	54	4.58	184
Insula	R	30	22	12	4.49	178
Postcentral gyrus	L	−50	−20	40	4.89	175
Precuneus	R	2	−78	28	4.76	165
Parahippocampal gyrus	L	−32	−10	−20	5.01	164
Cingulate gyrus	L	−4	−34	30	4.80	160
Precuneus	L	−18	−68	16	5.06	159
PCC	R	22	−58	18	5.78	155
Middle occipital gyrus	R	36	−86	−6	4.74	149
Cerebellum	L	−26	28	4	5.28	125

ACC: anterior cingulate cortex, PCC: posterior cingulate gyrus. Positive values: healthy subjects > aMCI, aMCI > AD, and healthy subjects > AD. Negative values: aMCI > healthy subjects, AD > aMCI, and AD > healthy subjects. Threshold: corrected < 0.05.