Assessment of Functional Characteristics of Amnestic Mild Cognitive Impairment and Alzheimer’s Disease Using Various Methods of Resting-State FMRI Analysis

Table 8

Results of post hoc two-sample -tests between every pair of the healthy subjects and patients with AD and aMCI groups in fALFF approach.

Brain regions	R/L	Coordinates; (mm)			Peak; value	Voxels
		Healthy subject versus aMCI
Middle temporal gyrus	L	−30	−72	24	3.89	256
Superior temporal gyrus	L	−56	8	0	4.32	143
Inferior parietal lobule	L	−42	−58	38	4.14	136
Inferior parietal lobule	L	−50	−46	22	4.14	131
aMCI versus AD
Parahippocampal gyrus	R	42	−30	−16	4.61	249
Cuneus	R	0	−72	6	4.23	173
Cerebellum	L	−26	−12	−36	4.48	163
Parahippocampal gyrus	R	34	−12	−28	4.60	135
Middle temporal gyrus	R	60	4	−22	4.04	131
Healthy subject versus AD
Inferior parietal lobule	R	−48	−62	42	5.37	2324
PCC	L	−8	−62	12	4.92	832
Fusiform gyrus	R	38	−40	−8	5.75	504
Middle frontal gyrus	L	−40	38	18	5.10	409
Middle temporal gyrus	L	−48	10	−32	4.79	399
Inferior parietal lobule	R	50	−40	46	4.33	242
Precuneus	R	26	−60	22	4.17	205
Medial frontal gyrus	R	10	58	22	4.95	198
Postcentral gyrus	L	−58	−26	38	4.75	191
Inferior frontal gyrus	R	48	22	16	4.85	167
Superior temporal gyrus	R	60	−46	14	3.92	163
Middle frontal gyrus	R	58	6	−22	4.97	147
Cuneus	R	14	−68	6	4.84	140
Postcentral gyrus	L	−52	2	10	4.65	136
Medial frontal gyrus	L	−2	52	−5	4.04	125

PCC: posterior cingulated cortex. Positive values: healthy subjects > aMCI, aMCI > AD, and healthy subjects > AD. Negative values: aMCI > healthy subjects, AD > aMCI, and AD > healthy subjects. Threshold: corrected < 0.05.