Activation of Apoptotic Signal in Endothelial Cells through Intracellular Signaling Molecules Blockade in Tumor-Induced Angiogenesis

Figure 7

Boolean network model output when no molecule is inhibited. The combinations of the input signals are shown below each subfigure. The iterations run from left to right in each subfigure. The white box corresponds to 1 (active) and the black box corresponds to 0 (inactive). In each subfigure, the 1st row is Cadherin signal status, the 2nd row is RTK signal status, and the 3rd row is integrin (ITG) signal status. The Rac status is shown in the 12th row. The input signals are constant during iterations. The initial states of other nodes in the network are chosen randomly. Nodes states change during the solution until a converged set of states is obtained for nodes. The last four rows are outputs that are proliferation, apoptosis, motility, and lumen formation, respectively.

(a) Cadherin = 0, ITG = 1, RTK = 1, and Rac = 0

(b) Cadherin = 0, ITG = 1, RTK = 1, and Rac = 1

(c) Cadherin = 1, ITG = 1, RTK = 1, and Rac = 0

(d) Cadherin = 1, ITG = 1, RTK = 1, and Rac = 1