Biotechnological and Agronomic Potential of Endophytic Pink-Pigmented Methylotrophic Methylobacterium spp.

Table 2

Omics studies in the Methylobacterium genus.

Organism	Approach	Findings	References
M. extorquens AM1	Proteome	Identify a PhyR stress regulator during phyllosphere colonization using 2D analysis.	[59]
M. extorquens AM1	Proteome	Proteomic comparison under single carbon (methanol) and multicarbon (succinate) growth in a gel free quantitative proteomic assay.	[134]
M. extorquens AM1	Proteome	Cytosolic protein differentially modulated under single carbon (methanol) and multicarbon (succinate) growth.	[135]
M. extorquens AM1	Proteome	Compare wild type with M. extorquens AM1 lacking isocitrate lyase (the key enzyme in the glyoxylate cycle) during growth on acetate, which was replaced by ethylmalonyl-CoA pathway.	[138]
M. extorquens DM4	Proteome	Differential proteomic analysis of cultures grown with DCM and with methanol elucidates growth metabolism in the presence of DCM.	[26]
M. extorquens CM4	Proteome and genome	Comparison of growth with one-carbon substrates: chloromethane and methanol, reporting the genes required for chloromethane utilization.	[140]
M. extorquens AM1	Proteogenome	Refined the annotation of protein coding genes and discover genes in M. extorquens AM1 genome.	[132]
M. extorquens AM1	Metabolomic	Analyze the metabolites produced during single carbon (methanol) and multicarbon (succinate) growth, providing clues to new pathways that are specifically linked to C1 metabolism.	[136]
M. extorquens AM1	Metabolomic	Metabolites produced by M. extorquens AM1 grown on two carbon sources, ethylamine (C2) and succinate (C4) using LC-based and GC-based methods showing differences in in pathways linked to C2 and C4 metabolism.	[137]
M. extorquens AM1	Transcriptome	Validate a microarray plataform comparing genes expressed during single carbon (methanol) and multicarbon (succinate) growth, pointing candidate genes in C1 metabolism.	[133]
M. extorquens AM1	Transcriptome	Elucidates the regulation of general stress regulator (PhyR) using microarray.	[139]
M. extorquens AM1 e DM4	Genome comparison	Genome comparison of M. extorquens strain AM1 (reference strain) and the dichloromethane-degrading strain DM4 concluding that rearrangements and horizontal gene transfer resulted in a great genomic plasticity.	[128]
Methylobacterium strains	Genome announcement	Six Methylobacterium strains adapted to different plant-associated niches and environmental: M. extorquens (PA1, CM4. BJ001), M. radiotolerans (JCM2831), M. nodulans (ORS2060), and Methylobacterium sp. 4-46	[130]
M. mesophilicum SR1.6/6	Genome announcement	Endophytic bacterium isolated from a surface-sterilized Citrus sinensis.	[127]
Methylobacterium sp. GXF4	Genome announcement	A xylem-associated bacterium isolated from Vitis vinifera L. grapevine.	[43]