Research Article

The Application of Classification and Regression Trees for the Triage of Women for Referral to Colposcopy and the Estimation of Risk for Cervical Intraepithelial Neoplasia: A Study Based on 1625 Cases with Incomplete Data from Molecular Tests

Table 2

Variables entered to the model.

Variable nameDescription Value range

CytologyThe result of the cytological examination expressed according to the Bethesda 2009 systemWNL, ASC-US, LGSIL, ASC-H, HGSIL, SCC, ADENO CA, and <blank> if there is no result

HPV DNA arrays
A6, A11, A16, A18, A26, A31, A33, A35, A39, A40, A42, A43, A44, A45, A51, A52, A53, A54, A56, A58, A59, A61, A62, A66, A68, A70, A71, A72, A73, A81, A82, A83, A84, A85, and A89
The existence of individual subtypes according to the arrays examination0 if the specific subtype is not found
1 if the specific subtype is found
<blank> if there is no result

Has HRPositive if one or more high risk subtypes were found during typingPositive, negative, or missing

Has LRPositive if one or more low risk subtypes were found during typingPositive, negative, or missing

Has any typePositive if one or more subtypes were found during typingPositive, negative, or missing

No HRThe number of high risk subtypes that were found during typingAn integer or missing

No LRThe number of low risk subtypes that were found during typingAn integer or missing

N16, N18, N31, N33, and N45The result of the E6/E7 mRNA test for the specific HPV subtype 0 if negative
1 if positive
<blank> if there is no result

FlowThe result of the identification of E6/E7 mRNA expression of high risk HPV using flow cytometry technique0 if negative (<1.5%)
1 if positive (>1.5%)
<blank> if there is no result

Flow %The result of E6/E7 mRNA expression of high risk HPV using flow cytometry technique expressed as a percentageA number or <blank> if there is no result

p16The result of the p16 immunocytochemical examination 0 if negative
1 if positive
<blank> if there is no result

AgeThe woman age at the time of examinationA positive number

ParousWoman parous status1 if she has born one or more children and 0 if not