African Flora Has the Potential to Fight Multidrug Resistance of Cancer

Figure 2

Cytotoxic phenolics isolated from African medicinal plants with documented activity on MDR cancer cells. Naringenin (7), kaempferol-3,7,4′-trimethylether (8), candidone (9), 4-hydroxy-2,6-di-(3′,4′-dimethoxyphenyl)-3,7dioxabicyclo-(3.3.0)octane (10), futokadsurin B (11), gancaonin Q (12), 6-prenylapigenin (13), 6,8-diprenyleriodictyol (14), 4-hydroxylonchocarpin (15), xanthone V₁ (16), 2-acetylfuro-1,4-naphthoquinone (17), 2,2′,5,6′-tetrahydroxybenzophenone (18), isogarcinol (19), isoxanthochymol (20), guttiferone E (21), abyssinone IV (22), sigmoidin I (23), atalantoflavone (24), sophorapterocarpan A (25), bidwillon A (26), neocyclomorusin (27), 6α-hydroxyphaseollidin (28), neobavaisoflavone (29), 4′-hydroxy-2′,6′-dimethoxychalcone (30), cardamomin (31), 2′,4′-dihydroxy-3′,6′-dimethoxychalcone (32), (S)-(–)-pinostrobin (33), (S)-(–)-onysilin (34), alpinetin (35), guieranone A (36), neobavaisoflavone (37), sigmoidin H (38), isoneorautenol (39), 8-hydroxycudraxanthone G (40), morusignin I (41), cudraxanthone I (42), and excelsaperoxide (43).