Influence of Genetic Variants in EGF and Other Genes on Hematological Traits in Korean Populations by a Genome-Wide Approach
Table 2
Associations with CAD and lipid profiles for loci-associated PLT with genome-wide significance.
Trait
SNP
Cytoband
Gene
CAD ( = 4,813)
TC ( = 8,842)
TG ( = 8,842)
LDL ( = 8,842)
HDL ( = 8,842)
OR (95% CI)
Effect size
Effect size
Effect size
Effect size
PLT
rs13091574
3q27.1
THPO
0.96 (0.86–1.07)
0.4571
−0.39 ± 0.72
0.5944
−1.63 ± 2.12
0.4426
−0.67 ± 0.65
0.3096
0.37 ± 0.21
0.0704
rs2282786
4q25
EGF
1.07 (0.97–1.17)
0.1803
−0.33 ± 0.62
0.5954
−2.40 ± 1.82
0.188
−0.05 ± 0.56
0.9282
−0.05 ± 0.17
0.7807
rs9469032
6p21.33
LY6G5C
1.15 (0.93–1.42)
0.1943
1.69 ± 1.51
0.2613
4.37 ± 4.47
0.3288
1.00 ± 1.37
0.4655
0.01 ± 0.43
0.9818
rs9277053
6p21.32
HLA-DOA-HLA-DPA1
—
—
0.93 ± 0.57
0.1059
0.16 ± 1.67
0.9252
0.79 ± 0.52
0.1296
0.14 ± 0.16
0.3875
rs9399137
6q23.3
HBS1L-MYB
—
—
−2.79 ± 0.58
1.87 × 10−6
−5.75 ± 1.72
8.41 × 10−4
−1.78 ± 0.53
8.02 × 10−4
−0.05 ± 0.17
0.7750
rs739496
12q24.12
SH2B3
0.82 (0.72–0.94)
3.70 × 10−3
0.99 ± 0.86
0.2522
4.77 ± 2.54
0.06059
0.05 ± 0.78
0.9487
0.36 ± 0.24
0.1420
rs1977081
22q13.31
PNPLA3
0.94 (0.87–1.03)
0.182
−2.03 ± 0.55
2.08 × 10−4
−5.94 ± 1.60
2.00 × 10−4
−1.30 ± 0.50
8.93 × 10−3
0.07 ± 0.16
0.6558
CHR, chromosome; BP, base position; PLT, platelet count; CAD, coronary artery disease; TC, total cholesterol; TG, triglyceride; LDL, LDL-cholesterol; HDL, HDL-cholesterol. Logistic and linear regression analyses adjusted by age and gender were performed. Effect sizes are shown as beta ± S.E.
