The Gastrointestinal Irritation of Polygala Saponins and Its Potential Mechanism In Vitro and In Vivo

Table 1

Effects of polygala saponins with different glycosyl on pentobarbital-induced sleeping duration in mice.

Groups	Dose (mg/kg)	Percentage of falling asleep (%)
Control	—	10
OJB	200	70^a
	100	70^a
TEN	200	60^a
	100	70^a
SNG	200	30
	100	20
EST	1	80^2a

Mark: mice were respectively administrated by intragastrical administration (I.G) with high and low doses (200 and 100 mg/kg) of the Onjisaponin B (OJB), tenuifolin (TEN), senegenin (SNG), and 1 mg/kg of estazolam (EST) for one time 30 min before pentobarbital treatment. Mice were administered with 25 mg/kg which was used as subhypnotic dose. Negative control groups were treated with equal volume of vehicle. . ^a; ^2a versus control.