The Gastrointestinal Irritation of Polygala Saponins and Its Potential Mechanism In Vitro and In Vivo

Table 2

Effects of polygala saponins with different glycosyls on pentobarbital-induced sleeping animal amount in mice.

Groups	Dose (mg/kg)	Sleep latency	Sleeping time (min)
Control	—	8.2 ± 2.0	18.2 ± 9.0
OJB	200	7.8 ± 2.6	35.6 ± 11.3^a
	100	7.0 ± 1.7	39.7 ± 14.2^a
TEN	200	8.4 ± 3.4	31.2 ± 7.4^a
	100	9.0 ± 2.9	28.6 ± 3.5^a
SNG	200	8.7 ± 2.9	27.1 ± 11.1^a
	100	7.9 ± 2.6	18.8 ± 11.0
EST	1	9.4 ± 4.1	26.8 ± 4.6^a

Mark: mice were, respectively, administrated by intragastrical administration (I.G) with high and low doses (200 and 100 mg/kg) of the Onjisaponin B (OJB), tenuifolin (TEN), senegenin (SNG), and 1 mg/kg of estazolam (EST) for one time 30 min before pentobarbital treatment. Mice were administered with 40 mg/kg. Negative control groups were treated with equal volume of vehicle. . ^a < 0.05 versus control.