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BioMed Research International
Volume 2015, Article ID 923861, 10 pages
http://dx.doi.org/10.1155/2015/923861
Research Article

Gray and White Matter Volumes and Cognitive Dysfunction in Drug-Naïve Newly Diagnosed Pediatric Epilepsy

1Department of Neurology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul 158-710, Republic of Korea
2Department of Neurology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon 630-723, Republic of Korea
3Department of Radiology, Ewha Womans University School of Medicine and Ewha Medical Research Institute, Seoul 158-710, Republic of Korea

Received 27 June 2014; Revised 20 April 2015; Accepted 21 June 2015

Academic Editor: Marco Giannelli

Copyright © 2015 Jung Hwa Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. E. Elger, C. Helmstaedter, and M. Kurthen, “Chronic epilepsy and cognition,” The Lancet Neurology, vol. 3, no. 11, pp. 663–672, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Vingerhoets, “Cognitive effects of seizures,” Seizure, vol. 15, no. 4, pp. 221–226, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. S. C. Tromp, J. W. Weber, A. P. Aldenkamp, J. Arends, I. vander Linden, and L. Diepman, “Relative influence of epileptic seizures and of epilepsy syndrome on cognitive function,” Journal of Child Neurology, vol. 18, no. 6, pp. 407–412, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Rzezak, D. Fuentes, C. A. Guimarães et al., “Frontal lobe dysfunction in children with temporal lobe epilepsy,” Pediatric Neurology, vol. 37, no. 3, pp. 176–185, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. P. S. Fastenau, C. S. Johnson, S. M. Perkins et al., “Neuropsychological status at seizure onset in children: risk factors for early cognitive deficits,” Neurology, vol. 73, no. 7, pp. 526–534, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Hermann, J. Jones, R. Sheth, C. Dow, M. Koehn, and M. Seidenberg, “Children with new-onset epilepsy: neuropsychological status and brain structure,” Brain, vol. 129, part 10, pp. 2609–2619, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. B. P. Hermann, J. E. Jones, D. C. Jackson, and M. Seidenberg, “Starting at the beginning: the neuropsychological status of children with new-onset epilepsies,” Epileptic Disorders, vol. 14, no. 1, pp. 12–21, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. K. J. Oostrom, A. Smeets-Schouten, C. L. J. J. Kruitwagen, A. C. B. Peters, and A. Jennekens-Schinkel, “Not only a matter of epilepsy: early problems of cognition and behavior in children with ‘epilepsy only’—a prospective, longitudinal, controlled study starting at diagnosis,” Pediatrics, vol. 112, no. 6 I, pp. 1338–1344, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. S. E. Kim, J. H. Lee, H. K. Chung, S. M. Lim, and H. W. Lee, “Alterations in white matter microstructures and cognitive dysfunctions in benign childhood epilepsy with centrotemporal spikes,” European Journal of Neurology, vol. 21, no. 5, pp. 708–717, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. B. Bell, J. J. Lin, M. Seidenberg, and B. Hermann, “The neurobiology of cognitive disorders in temporal lobe epilepsy,” Nature Reviews Neurology, vol. 7, no. 3, pp. 154–164, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. R. Caplan, P. Siddarth, L. Stahl et al., “Childhood absence epilepsy: behavioral, cognitive, and linguistic comorbidities,” Epilepsia, vol. 49, no. 11, pp. 1838–1846, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. T. F. Pascalicchio, G. M. D. A. Filho, M. H. D. S. Noffs et al., “Neuropsychological profile of patients with juvenile myoclonic epilepsy: a controlled study of 50 patients,” Epilepsy & Behavior, vol. 10, no. 2, pp. 263–267, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. B. P. Hermann, K. Dabbs, T. Becker et al., “Brain development in children with new onset epilepsy: a prospective controlled cohort investigation,” Epilepsia, vol. 51, no. 10, pp. 2038–2046, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. J. A. Lawson, S. Vogrin, A. F. Bleasel et al., “Predictors of hippocampal, cerebral, and cerebellar volume reduction in childhood epilepsy,” Epilepsia, vol. 41, no. 12, pp. 1540–1545, 2000. View at Publisher · View at Google Scholar · View at Scopus
  15. J. A. Lawson, M. J. Cook, S. Vogrin et al., “Clinical, EEG, and quantitative MRI differences in pediatric frontal and temporal lobe epilepsy,” Neurology, vol. 58, no. 5, pp. 723–729, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. F. Cormack, D. G. Gadian, F. Vargha-Khadem, J. H. Cross, A. Connelly, and T. Baldeweg, “Extra-hippocampal grey matter density abnormalities in paediatric mesial temporal sclerosis,” NeuroImage, vol. 27, no. 3, pp. 635–643, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Dabbs, J. E. Jones, D. C. Jackson, M. Seidenberg, and B. P. Hermann, “Patterns of cortical thickness and the Child Behavior Checklist in childhood epilepsy,” Epilepsy and Behavior, vol. 29, no. 1, pp. 198–204, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. S. A. Baxendale, W. van Paesschen, P. J. Thompson et al., “The relationship between quantitative MRI and neuropsychological functioning in temporal lobe epilepsy,” Epilepsia, vol. 39, no. 2, pp. 158–166, 1998. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Bernasconi, S. Duchesne, A. Janke, J. Lerch, D. L. Collins, and A. Bernasconi, “Whole-brain voxel-based statistical analysis of gray matter and white matter in temporal lobe epilepsy,” NeuroImage, vol. 23, no. 2, pp. 717–723, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Dow, M. Seidenberg, and B. Hermann, “Relationship between information processing speed in temporal lobe epilepsy and white matter volume,” Epilepsy and Behavior, vol. 5, no. 6, pp. 919–925, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. H. R. Griffith, R. W. Pyzalski, M. Seidenberg, and B. P. Hermann, “Memory relationships between MRI volumes and resting PET metabolism of medial temporal lobe structures,” Epilepsy and Behavior, vol. 5, no. 5, pp. 669–676, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. B. Hermann, M. Seidenberg, L. Sears et al., “Cerebellar atrophy in temporal lobe epilepsy affects procedural memory,” Neurology, vol. 63, no. 11, pp. 2129–2131, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. R. C. Martin, J. W. Hugg, D. L. Roth et al., “MRI extrahippocampal volumes and visual memory: correlations independent of MRI hippocampal volumes in temporal lobe epilepsy patients,” Journal of the International Neuropsychological Society, vol. 5, no. 6, pp. 540–548, 1999. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Seidenberg, K. G. Kelly, J. Parrish et al., “Ipsilateral and contralateral MRI volumetric abnormalities in chronic unilateral temporal lobe epilepsy and their clinical correlates,” Epilepsia, vol. 46, no. 3, pp. 420–430, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. J. A. Lawson, M. J. Cook, A. F. Bleasel, V. Nayanar, K. F. Morris, and A. M. E. Bye, “Quantitative MRI in outpatient childhood epilepsy,” Epilepsia, vol. 38, no. 12, pp. 1289–1293, 1997. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Engel Jr., “A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE task force on classification and terminology,” Epilepsia, vol. 42, no. 6, pp. 796–803, 2001. View at Publisher · View at Google Scholar · View at Scopus
  27. K. W. Park, J. R. Yoon, H. J. Park, and K. W. Kim, Manual for the Korean Education Development Institute-Wechsler Intelligence Scale for Children, Korean Education Development Institute, Seoul, Republic of Korea, 1991.
  28. K. J. Kwak, H. W. Park, and C. T. Kim, “The standardization study for the Korean Wechsler intelligence scale for children—third edition (1): reliability and validity,” Korean Journal of Developmental Psychology, vol. 15, no. 1, pp. 19–33, 2002. View at Google Scholar
  29. M. S. Shin, M. Park, and J. Stroop, Stroop Color and Word Test: A Manual for Clinical and Experimental Uses, Hakjisa, Seoul, Republic of Korea, 2007.
  30. J. B. Lee, J. S. Kim, W. S. Seo, H. J. Shin, D. S. Bai, and H. L. Lee, “The validity and reliability of computerized neurocognitive function test in the elementary school child,” Korean Journal of Psychosomatic Medicine, vol. 11, pp. 97–117, 2003. View at Google Scholar
  31. C. D. Good, I. S. Johnsrude, J. Ashburner, R. N. A. Henson, K. J. Friston, and R. S. J. Frackowiak, “A voxel-based morphometric study of ageing in 465 normal adult human brains,” NeuroImage, vol. 14, no. 1, part 1, pp. 21–36, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. G. R. Ridgway, S. M. D. Henley, J. D. Rohrer, R. I. Scahill, J. D. Warren, and N. C. Fox, “Ten simple rules for reporting voxel-based morphometry studies,” NeuroImage, vol. 40, no. 4, pp. 1429–1435, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. S. S. Keller, M. Wilke, U. C. Wieshmann, V. A. Sluming, and N. Roberts, “Comparison of standard and optimized voxel-based morphometry for analysis of brain changes associated with temporal lobe epilepsy,” NeuroImage, vol. 23, no. 3, pp. 860–868, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. U. Yoon, V. S. Fonov, D. Perusse, and A. C. Evans, “The effect of template choice on morphometric analysis of pediatric brain data,” NeuroImage, vol. 45, no. 3, pp. 769–777, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Wilke, V. J. Schmithorst, and S. K. Holland, “Assessment of spatial normalization of whole-brain magnetic resonance images in children,” Human Brain Mapping, vol. 17, no. 1, pp. 48–60, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. J. Ashburner and K. J. Friston, “Voxel-based morphometry—the methods,” NeuroImage, vol. 11, no. 6, pp. 805–821, 2000. View at Publisher · View at Google Scholar · View at Scopus
  37. J. H. Kim, J. K. Lee, S.-B. Koh et al., “Regional grey matter abnormalities in juvenile myoclonic epilepsy: a voxel-based morphometry study,” NeuroImage, vol. 37, no. 4, pp. 1132–1137, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. K. J. Worsley, M. Andermann, T. Koulis, D. MacDonald, and A. C. Evans, “Detecting changes in nonisotropic images,” Human Brain Mapping, vol. 8, no. 2-3, pp. 98–101, 1999. View at Google Scholar · View at Scopus
  39. C. R. Genovese, N. A. Lazar, and T. Nichols, “Thresholding of statistical maps in functional neuroimaging using the false discovery rate,” NeuroImage, vol. 15, no. 4, pp. 870–878, 2002. View at Publisher · View at Google Scholar · View at Scopus
  40. J. L. Lancaster, M. G. Woldorff, L. M. Parsons et al., “Automated Talairach atlas labels for functional brain mapping,” Human Brain Mapping, vol. 10, no. 3, pp. 120–131, 2000. View at Publisher · View at Google Scholar · View at Scopus
  41. A. Verrotti, C. D'Egidio, S. Agostinelli, P. Parisi, F. Chiarelli, and G. Coppola, “Cognitive and linguistic abnormalities in benign childhood epilepsy with centrotemporal spikes,” Acta Paediatrica, International Journal of Paediatrics, vol. 100, no. 5, pp. 768–772, 2011. View at Publisher · View at Google Scholar · View at Scopus
  42. G. L. Holmes, Y. Ben-Ari, and A. Zipursky, “The neurobiology and consequences of epilepsy in the developing brain,” Pediatric Research, vol. 49, no. 3, pp. 320–325, 2001. View at Publisher · View at Google Scholar · View at Scopus
  43. N. Gogtay, J. N. Giedd, L. Lusk et al., “Dynamic mapping of human cortical development during childhood through early adulthood,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 21, pp. 8174–8179, 2004. View at Publisher · View at Google Scholar · View at Scopus
  44. S. Frangou, X. Chitins, and S. C. R. Williams, “Mapping IQ and gray matter density in healthy young people,” NeuroImage, vol. 23, no. 3, pp. 800–805, 2004. View at Publisher · View at Google Scholar · View at Scopus
  45. M. Wilke, J.-H. Sohn, A. W. Byars, and S. K. Holland, “Bright spots: correlations of gray matter volume with IQ in a normal pediatric population,” NeuroImage, vol. 20, no. 1, pp. 202–215, 2003. View at Publisher · View at Google Scholar · View at Scopus
  46. J. Ashburner, “A fast diffeomorphic image registration algorithm,” NeuroImage, vol. 38, no. 1, pp. 95–113, 2007. View at Publisher · View at Google Scholar · View at Scopus